(R)-2-cyclohexyl-1-(naphthalen-2-yl)ethyl 2-mercapto-2-methylpropanoate

Base Information

Chemical Name:(R)-2-cyclohexyl-1-(naphthalen-2-yl)ethyl 2-mercapto-2-methylpropanoate
CAS No.:1442650-08-9
Molecular Formula:C₂₂H₂₈O₂S
Molecular Weight:356.529
Hs Code.:

Synonyms:(R)-2-cyclohexyl-1-(naphthalen-2-yl)ethyl 2-mercapto-2-methylpropanoate

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Chemical Property of (R)-2-cyclohexyl-1-(naphthalen-2-yl)ethyl 2-mercapto-2-methylpropanoate

Chemical Property:

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Technology Process of (R)-2-cyclohexyl-1-(naphthalen-2-yl)ethyl 2-mercapto-2-methylpropanoate

There total 5 articles about (R)-2-cyclohexyl-1-(naphthalen-2-yl)ethyl 2-mercapto-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1442650-07-8
(R)-2-cyclohexyl-1-(naphthalen-2-yl)ethyl 2-(benzoylthio)-2-methylpropanoate

: 1442650-08-9
(R)-2-cyclohexyl-1-(naphthalen-2-yl)ethyl 2-mercapto-2-methylpropanoate

Guidance literature:: With sodium thiomethoxide; In methanol; dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/ja4034999

Reference yield:

: 1071656-38-6
2-cyclohexyl-1-(naphthalen-2-yl)ethan-1-one

: 1442650-08-9
(R)-2-cyclohexyl-1-(naphthalen-2-yl)ethyl 2-mercapto-2-methylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; dimethylsulfide borane complex / toluene / 20 h / -20 °C / Inert atmosphere

2: dicyclohexyl-carbodiimide; dmap / dichloromethane / 20 °C / Inert atmosphere

3: sodium thiomethoxide / dichloromethane; methanol / 0.5 h / 20 °C / Inert atmosphere

With dmap; dimethylsulfide borane complex; dicyclohexyl-carbodiimide; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; sodium thiomethoxide; In methanol; dichloromethane; toluene;
DOI:10.1021/ja4034999

Reference yield:

: 2550-36-9
Cyclohexylmethyl bromide

: 1442650-08-9
(R)-2-cyclohexyl-1-(naphthalen-2-yl)ethyl 2-mercapto-2-methylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: magnesium; iodine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

1.2: 1.5 h / 0 °C / Inert atmosphere

2.1: (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; dimethylsulfide borane complex / toluene / 20 h / -20 °C / Inert atmosphere

3.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 20 °C / Inert atmosphere

4.1: sodium thiomethoxide / dichloromethane; methanol / 0.5 h / 20 °C / Inert atmosphere

With dmap; dimethylsulfide borane complex; iodine; magnesium; dicyclohexyl-carbodiimide; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; sodium thiomethoxide; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/ja4034999