(R)-2-cyclohexyl-1-(naphthalen-2-yl)ethyl 2-(benzoylthio)-2-methylpropanoate

Base Information

Chemical Name:(R)-2-cyclohexyl-1-(naphthalen-2-yl)ethyl 2-(benzoylthio)-2-methylpropanoate
CAS No.:1442650-07-8
Molecular Formula:C₂₉H₃₂O₃S
Molecular Weight:460.637
Hs Code.:

Synonyms:(R)-2-cyclohexyl-1-(naphthalen-2-yl)ethyl 2-(benzoylthio)-2-methylpropanoate

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Chemical Property of (R)-2-cyclohexyl-1-(naphthalen-2-yl)ethyl 2-(benzoylthio)-2-methylpropanoate

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Technology Process of (R)-2-cyclohexyl-1-(naphthalen-2-yl)ethyl 2-(benzoylthio)-2-methylpropanoate

There total 4 articles about (R)-2-cyclohexyl-1-(naphthalen-2-yl)ethyl 2-(benzoylthio)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 2-(benzoylthio)-2-methylpropanoic acid

: 1430475-44-7
(R)-2-cyclohexyl-1-(naphthalen-2-yl)ethan-1-ol

: 1442650-07-8
(R)-2-cyclohexyl-1-(naphthalen-2-yl)ethyl 2-(benzoylthio)-2-methylpropanoate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/ja4034999

Reference yield:

: 1071656-38-6
2-cyclohexyl-1-(naphthalen-2-yl)ethan-1-one

: 1442650-07-8
(R)-2-cyclohexyl-1-(naphthalen-2-yl)ethyl 2-(benzoylthio)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; dimethylsulfide borane complex / toluene / 20 h / -20 °C / Inert atmosphere

2: dicyclohexyl-carbodiimide; dmap / dichloromethane / 20 °C / Inert atmosphere

With dmap; dimethylsulfide borane complex; dicyclohexyl-carbodiimide; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; In dichloromethane; toluene;
DOI:10.1021/ja4034999

Reference yield:

: 2550-36-9
Cyclohexylmethyl bromide

: 1442650-07-8
(R)-2-cyclohexyl-1-(naphthalen-2-yl)ethyl 2-(benzoylthio)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium; iodine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

1.2: 1.5 h / 0 °C / Inert atmosphere

2.1: (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; dimethylsulfide borane complex / toluene / 20 h / -20 °C / Inert atmosphere

3.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 20 °C / Inert atmosphere

With dmap; dimethylsulfide borane complex; iodine; magnesium; dicyclohexyl-carbodiimide; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ja4034999