Technology Process of N-(2-S-propanoic acid)-6-<(diphenoxyphosphinyl)oxy>hexanamide
There total 4 articles about N-(2-S-propanoic acid)-6-<(diphenoxyphosphinyl)oxy>hexanamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: aq. NaOH / 2 h / Heating
2: 83 percent / pyridine / 12 h / Ambient temperature
3: 0.87 g / 1-hydroxybenzotriazole monohydrate, 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate, pyridine / dimethylformamide; CH2Cl2 / 24 h / Ambient temperature
4: formic acid / 48 h / Ambient temperature
With
pyridine; sodium hydroxide; formic acid; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; 1-hydroxybenzotriazol-hydrate;
In
pyridine; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo981895p
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 83 percent / pyridine / 12 h / Ambient temperature
2: 0.87 g / 1-hydroxybenzotriazole monohydrate, 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate, pyridine / dimethylformamide; CH2Cl2 / 24 h / Ambient temperature
3: formic acid / 48 h / Ambient temperature
With
pyridine; formic acid; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; 1-hydroxybenzotriazol-hydrate;
In
pyridine; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo981895p
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 0.87 g / 1-hydroxybenzotriazole monohydrate, 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate, pyridine / dimethylformamide; CH2Cl2 / 24 h / Ambient temperature
2: formic acid / 48 h / Ambient temperature
With
pyridine; formic acid; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; 1-hydroxybenzotriazol-hydrate;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo981895p
