N-(4-methoxyphenyl)-N-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride

Base Information

• Chemical Name: N-(4-methoxyphenyl)-N-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride
• CAS No.: 1452392-88-9
• Molecular Formula: C₁₅H₁₇N₃O*ClH
• Molecular Weight: 291.78
• Mol file: 1452392-88-9.mol

Synonyms:N-(4-methoxyphenyl)-N-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride

Chemical Property of N-(4-methoxyphenyl)-N-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-methoxyphenyl)-N-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride

There total 6 articles about N-(4-methoxyphenyl)-N-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-(4-methoxyphenyl)-N-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine (1452392-79-8) → N-(4-methoxyphenyl)-N-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride (1452392-88-9)

Guidance literature:

With hydrogenchloride; In diethyl ether;

DOI:10.1021/jm400639z

Reference yield:

methyl 2-oxocyclopentane-1-carboxylate (10472-24-9,265317-94-0) → N-(4-methoxyphenyl)-N-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride (1452392-88-9)

Guidance literature:

Multi-step reaction with 6 steps

1: ammonium formate / methanol / 24 h / Reflux

2: acetic anhydride / 4 h / 20 °C / Cooling with ice

3: ammonium formate; formamide / 16 h / 20 - 150 °C

4: trichlorophosphate / 3 h / Reflux

5: hydrogenchloride / isopropyl alcohol / Reflux

6: hydrogenchloride / diethyl ether

With hydrogenchloride; ammonium formate; acetic anhydride; formamide; trichlorophosphate; In methanol; diethyl ether; isopropyl alcohol;

DOI:10.1021/jm400639z

Reference yield:

2-formamidocyclopentene-1-carboxylic acid methyl ester (1452392-78-7) → N-(4-methoxyphenyl)-N-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride (1452392-88-9)

Guidance literature:

Multi-step reaction with 4 steps

1: ammonium formate; formamide / 16 h / 20 - 150 °C

2: trichlorophosphate / 3 h / Reflux

3: hydrogenchloride / isopropyl alcohol / Reflux

4: hydrogenchloride / diethyl ether

With hydrogenchloride; ammonium formate; formamide; trichlorophosphate; In diethyl ether; isopropyl alcohol;

DOI:10.1021/jm400639z

upstream raw materials:

methyl 2-oxocyclopentane-1-carboxylate

2aminocyclopentene-1-carboxylic acid methyl ester

2-formamidocyclopentene-1-carboxylic acid methyl ester

6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one