(2E)-2-<2-<2-acetyl(p-toluenesulfonyl)amino-5-(tert-butyldiphenylsilyl)oxymethylphenyl>ethylidene>-5,6-dimethyl-5-hepten-1-ol

Base Information

Chemical Name:(2E)-2-<2-<2-acetyl(p-toluenesulfonyl)amino-5-(tert-butyldiphenylsilyl)oxymethylphenyl>ethylidene>-5,6-dimethyl-5-hepten-1-ol
CAS No.:119139-42-3
Molecular Formula:C₄₃H₅₃NO₅SSi
Molecular Weight:724.049
Hs Code.:

Synonyms:(2E)-2-<2-<2-acetyl(p-toluenesulfonyl)amino-5-(tert-butyldiphenylsilyl)oxymethylphenyl>ethylidene>-5,6-dimethyl-5-hepten-1-ol

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Chemical Property of (2E)-2-<2-<2-acetyl(p-toluenesulfonyl)amino-5-(tert-butyldiphenylsilyl)oxymethylphenyl>ethylidene>-5,6-dimethyl-5-hepten-1-ol

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Technology Process of (2E)-2-<2-<2-acetyl(p-toluenesulfonyl)amino-5-(tert-butyldiphenylsilyl)oxymethylphenyl>ethylidene>-5,6-dimethyl-5-hepten-1-ol

There total 15 articles about (2E)-2-<2-<2-acetyl(p-toluenesulfonyl)amino-5-(tert-butyldiphenylsilyl)oxymethylphenyl>ethylidene>-5,6-dimethyl-5-hepten-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5072-70-8
1-bromo-2,3-dimethyl-2-butene

: 119139-42-3
(2E)-2-<2-<2-acetyl(p-toluenesulfonyl)amino-5-(tert-butyldiphenylsilyl)oxymethylphenyl>ethylidene>-5,6-dimethyl-5-hepten-1-ol

Guidance literature:: Multi-step reaction with 3 steps

2: 87 percent / CH₂Cl₂ / 52 h / Ambient temperature

In dichloromethane;
DOI:10.1246/cl.1988.909

Reference yield:

: 59816-84-1
ethyl 4-amino-3-(2-propenyl)benzoate

: 119139-42-3
(2E)-2-<2-<2-acetyl(p-toluenesulfonyl)amino-5-(tert-butyldiphenylsilyl)oxymethylphenyl>ethylidene>-5,6-dimethyl-5-hepten-1-ol

Guidance literature:: Multi-step reaction with 9 steps

1: 100 percent / pyridine / CH₂Cl₂ / 17 h / Ambient temperature

2: 95 percent / LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

3: 82 percent / imidazole / dimethylformamide / 85 h / 60 °C

4: 1.) aq. OsO₄, 2.) NaIO₄ / 1.) THF, RT, 30 min, 2.) THF, RT, 2 h

5: 87 percent / CH₂Cl₂ / 52 h / Ambient temperature

6: 92 percent / DIBALH / toluene / 0.5 h / -15 °C

7: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

8: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

9: aq. citric acid*H₂O / diethyl ether; methanol / 0.83 h / Ambient temperature

With pyridine; 1H-imidazole; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; diisobutylaluminium hydride; triethylamine; citric acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/0040-4020(96)00608-4

Reference yield:

: 119139-40-1
5-(tert-butyldiphenylsilyl)oxymethyl-1-(p-toluenesulfonyl)-2-indolinole

: 119139-42-3
(2E)-2-<2-<2-acetyl(p-toluenesulfonyl)amino-5-(tert-butyldiphenylsilyl)oxymethylphenyl>ethylidene>-5,6-dimethyl-5-hepten-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / CH₂Cl₂ / 52 h / Ambient temperature

2: 92 percent / DIBALH / toluene / 0.5 h / -15 °C

3: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

4: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

5: aq. citric acid*H₂O / diethyl ether; methanol / 0.83 h / Ambient temperature

With diisobutylaluminium hydride; triethylamine; citric acid; In methanol; diethyl ether; dichloromethane; toluene;
DOI:10.1016/0040-4020(96)00608-4