N-Acetyl-N-[4-(tert-butyl-diphenyl-silanyloxymethyl)-2-((E)-6,7-dimethyl-3-trimethylsilanyloxymethyl-octa-2,6-dienyl)-phenyl]-4-methyl-benzenesulfonamide

Base Information

• Chemical Name: N-Acetyl-N-[4-(tert-butyl-diphenyl-silanyloxymethyl)-2-((E)-6,7-dimethyl-3-trimethylsilanyloxymethyl-octa-2,6-dienyl)-phenyl]-4-methyl-benzenesulfonamide
• CAS No.: 181368-97-8
• Molecular Formula: C₄₆H₆₁NO₅SSi₂
• Molecular Weight: 796.231
• Mol file: 181368-97-8.mol

Synonyms:

Chemical Property of N-Acetyl-N-[4-(tert-butyl-diphenyl-silanyloxymethyl)-2-((E)-6,7-dimethyl-3-trimethylsilanyloxymethyl-octa-2,6-dienyl)-phenyl]-4-methyl-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Acetyl-N-[4-(tert-butyl-diphenyl-silanyloxymethyl)-2-((E)-6,7-dimethyl-3-trimethylsilanyloxymethyl-octa-2,6-dienyl)-phenyl]-4-methyl-benzenesulfonamide

There total 11 articles about N-Acetyl-N-[4-(tert-butyl-diphenyl-silanyloxymethyl)-2-((E)-6,7-dimethyl-3-trimethylsilanyloxymethyl-octa-2,6-dienyl)-phenyl]-4-methyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetyl chloride (75-36-5) + N-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-2-((E)-6,7-dimethyl-3-trimethylsilanyloxymethyl-octa-2,6-dienyl)-phenyl]-4-methyl-benzenesulfonamide (181368-96-7) → N-Acetyl-N-[4-(tert-butyl-diphenyl-silanyloxymethyl)-2-((E)-6,7-dimethyl-3-trimethylsilanyloxymethyl-octa-2,6-dienyl)-phenyl]-4-methyl-benzenesulfonamide (181368-97-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1016/0040-4020(96)00608-4

Reference yield:

ethyl 4-amino-3-(2-propenyl)benzoate (59816-84-1) → N-Acetyl-N-[4-(tert-butyl-diphenyl-silanyloxymethyl)-2-((E)-6,7-dimethyl-3-trimethylsilanyloxymethyl-octa-2,6-dienyl)-phenyl]-4-methyl-benzenesulfonamide (181368-97-8)

Guidance literature:

Multi-step reaction with 8 steps

1: 100 percent / pyridine / CH₂Cl₂ / 17 h / Ambient temperature

2: 95 percent / LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

3: 82 percent / imidazole / dimethylformamide / 85 h / 60 °C

4: 1.) aq. OsO₄, 2.) NaIO₄ / 1.) THF, RT, 30 min, 2.) THF, RT, 2 h

5: 87 percent / CH₂Cl₂ / 52 h / Ambient temperature

6: 92 percent / DIBALH / toluene / 0.5 h / -15 °C

7: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

8: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

With pyridine; 1H-imidazole; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1016/0040-4020(96)00608-4

Reference yield:

methyl 5,6-dimethyl-2-triphenylphosphoranylidene-5-heptenoate (119139-47-8) → N-Acetyl-N-[4-(tert-butyl-diphenyl-silanyloxymethyl)-2-((E)-6,7-dimethyl-3-trimethylsilanyloxymethyl-octa-2,6-dienyl)-phenyl]-4-methyl-benzenesulfonamide (181368-97-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 87 percent / CH₂Cl₂ / 52 h / Ambient temperature

2: 92 percent / DIBALH / toluene / 0.5 h / -15 °C

3: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

4: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

With diisobutylaluminium hydride; triethylamine; In dichloromethane; toluene;

DOI:10.1016/0040-4020(96)00608-4

upstream raw materials:

acetyl chloride

N-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-2-((E)-6,7-dimethyl-3-trimethylsilanyloxymethyl-octa-2,6-dienyl)-phenyl]-4-methyl-benzenesulfonamide

ethyl 4-amino-3-(2-propenyl)benzoate

methyl 5,6-dimethyl-2-triphenylphosphoranylidene-5-heptenoate

Downstream raw materials:

Methanesulfonic acid (2S,3S)-3-[2-[acetyl-(toluene-4-sulfonyl)-amino]-5-(tert-butyl-diphenyl-silanyloxymethyl)-benzyl]-2-(3,4-dimethyl-pent-3-enyl)-oxiranylmethyl ester

(4aS,9aS)-7-(tert-Butyl-diphenyl-silanyloxymethyl)-4a-(3,4-dimethyl-pent-3-enyl)-2,2-dimethyl-10-(toluene-4-sulfonyl)-4a,9,9a,10-tetrahydro-4H-1,3-dioxa-10-aza-anthracene

Acetic acid (S)-1-[5-(tert-butyl-diphenyl-silanyloxymethyl)-2-(toluene-4-sulfonylamino)-benzyl]-5,6-dimethyl-2-methylene-hept-5-enyl ester

(2S,3S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2-(3,4-dimethyl-pent-3-enyl)-2-hydroxymethyl-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-quinolin-3-ol