2-diazo-malonic acid 5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester methyl ester

Base Information

• Chemical Name: 2-diazo-malonic acid 5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester methyl ester
• CAS No.: 276870-77-0
• Molecular Formula: C₂₉H₃₃N₅O₇Si
• Molecular Weight: 591.696

Synonyms:2-diazo-malonic acid 5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester methyl ester

Chemical Property of 2-diazo-malonic acid 5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester methyl ester

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Technology Process of 2-diazo-malonic acid 5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester methyl ester

There total 3 articles about 2-diazo-malonic acid 5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → 2-diazo-malonic acid 5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester methyl ester (276870-77-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 20 °C

2: DMAP / toluene / Heating

With pyridine; dmap; In toluene; 1: Etherification / 2: Transesterification;

DOI:10.1039/b000524j

Reference yield:

2'-Deoxycytidine (951-77-9) → 2-diazo-malonic acid 5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester methyl ester (276870-77-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 20 °C

2: DMAP / toluene / Heating

With pyridine; dmap; In toluene; 1: Etherification / 2: Transesterification;

DOI:10.1039/b000524j

Reference yield:

dimethyl diazomalonate (6773-29-1) + 4-amino-1-((2R,4S,5R)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-4-hydroxytetrahydrofuran-2-yl)pyrimidin-2(1H)-one (276870-95-2) → 2-diazo-malonic acid 5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester methyl ester (276870-77-0)

Guidance literature:

With dmap; In toluene; Heating;

DOI:10.1039/b000524j

upstream raw materials:

dimethyl diazomalonate

4-amino-1-((2R,4S,5R)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-4-hydroxytetrahydrofuran-2-yl)pyrimidin-2(1H)-one

tert-butylchlorodiphenylsilane

2'-Deoxycytidine

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