triethylammonium 2,3,5-tri-O-benzoyl-6-deoxy-6-fluoro-α-D-galactofuranose monophosphate

Base Information

• Chemical Name: triethylammonium 2,3,5-tri-O-benzoyl-6-deoxy-6-fluoro-α-D-galactofuranose monophosphate
• CAS No.: 1370711-69-5
• Molecular Formula: C₆H₁₅N*C₂₇H₂₄FO₁₁P
• Molecular Weight: 675.645
• Mol file: 1370711-69-5.mol

Synonyms:triethylammonium 2,3,5-tri-O-benzoyl-6-deoxy-6-fluoro-α-D-galactofuranose monophosphate

Chemical Property of triethylammonium 2,3,5-tri-O-benzoyl-6-deoxy-6-fluoro-α-D-galactofuranose monophosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of triethylammonium 2,3,5-tri-O-benzoyl-6-deoxy-6-fluoro-α-D-galactofuranose monophosphate

There total 3 articles about triethylammonium 2,3,5-tri-O-benzoyl-6-deoxy-6-fluoro-α-D-galactofuranose monophosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

dibenzyl 2,3,5-tri-O-benzoyl-6-deoxy-6-fluoro-α-D-galactofuranose monophosphate (1370711-67-3) + triethylamine (121-44-8) → triethylammonium 2,3,5-tri-O-benzoyl-6-deoxy-6-fluoro-α-D-galactofuranose monophosphate (1370711-69-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 1.5h;

DOI:10.1021/ja301723p

Reference yield:

1-O-acetyl-2,3,5-tri-O-benzoyl-6-deoxy-6-fluoro-D-galactofuranose (1370711-80-0) → triethylammonium 2,3,5-tri-O-benzoyl-6-deoxy-6-fluoro-α-D-galactofuranose monophosphate (1370711-69-5)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen bromide; acetic acid / dichloromethane / 4.33 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / toluene / 1 h / 20 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / ethyl acetate / 1.5 h / 20 °C

With palladium 10% on activated carbon; hydrogen bromide; hydrogen; acetic acid; triethylamine; In dichloromethane; ethyl acetate; toluene;

DOI:10.1021/ja301723p

Reference yield:

C27H22BrFO7 → triethylammonium 2,3,5-tri-O-benzoyl-6-deoxy-6-fluoro-α-D-galactofuranose monophosphate (1370711-69-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / toluene / 1 h / 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 1.5 h / 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; In ethyl acetate; toluene;

DOI:10.1021/ja301723p

upstream raw materials:

1-O-acetyl-2,3,5-tri-O-benzoyl-6-deoxy-6-fluoro-D-galactofuranose

dibenzyl 2,3,5-tri-O-benzoyl-6-deoxy-6-fluoro-α-D-galactofuranose monophosphate

triethylamine