dibenzyl 2,3,5-tri-O-benzoyl-6-deoxy-6-fluoro-α-D-galactofuranose monophosphate

Base Information

• Chemical Name: dibenzyl 2,3,5-tri-O-benzoyl-6-deoxy-6-fluoro-α-D-galactofuranose monophosphate
• CAS No.: 1370711-67-3
• Molecular Formula: C₄₁H₃₆FO₁₁P
• Molecular Weight: 754.702
• Mol file: 1370711-67-3.mol

Synonyms:dibenzyl 2,3,5-tri-O-benzoyl-6-deoxy-6-fluoro-α-D-galactofuranose monophosphate

Chemical Property of dibenzyl 2,3,5-tri-O-benzoyl-6-deoxy-6-fluoro-α-D-galactofuranose monophosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of dibenzyl 2,3,5-tri-O-benzoyl-6-deoxy-6-fluoro-α-D-galactofuranose monophosphate

There total 2 articles about dibenzyl 2,3,5-tri-O-benzoyl-6-deoxy-6-fluoro-α-D-galactofuranose monophosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phosphoric acid dibenzyl ester (1623-08-1) + C27H22BrFO7 → dibenzyl 2,3,5-tri-O-benzoyl-6-deoxy-6-fluoro-α-D-galactofuranose monophosphate (1370711-67-3)

Guidance literature:

With triethylamine; In toluene; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ja301723p

Reference yield:

1-O-acetyl-2,3,5-tri-O-benzoyl-6-deoxy-6-fluoro-D-galactofuranose (1370711-80-0) → dibenzyl 2,3,5-tri-O-benzoyl-6-deoxy-6-fluoro-α-D-galactofuranose monophosphate (1370711-67-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen bromide; acetic acid / dichloromethane / 4.33 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / toluene / 1 h / 20 °C / Inert atmosphere

With hydrogen bromide; acetic acid; triethylamine; In dichloromethane; toluene;

DOI:10.1021/ja301723p

Reference yield: 90.0%

dibenzyl 2,3,5-tri-O-benzoyl-6-deoxy-6-fluoro-α-D-galactofuranose monophosphate (1370711-67-3) + triethylamine (121-44-8) → triethylammonium 2,3,5-tri-O-benzoyl-6-deoxy-6-fluoro-α-D-galactofuranose monophosphate (1370711-69-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 1.5h;

DOI:10.1021/ja301723p

upstream raw materials:

1-O-acetyl-2,3,5-tri-O-benzoyl-6-deoxy-6-fluoro-D-galactofuranose

phosphoric acid dibenzyl ester

Downstream raw materials:

triethylammonium 2,3,5-tri-O-benzoyl-6-deoxy-6-fluoro-α-D-galactofuranose monophosphate