(R)-<(tert-butyldimethylsilyl)oxy>phenylacetic acid

Base Information

• Chemical Name: (R)-<(tert-butyldimethylsilyl)oxy>phenylacetic acid
• CAS No.: 119619-48-6
• Molecular Formula: C₁₄H₂₂O₃Si
• Molecular Weight: 266.412
• Mol file: 119619-48-6.mol

Synonyms:(R)-<(tert-butyldimethylsilyl)oxy>phenylacetic acid

Chemical Property of (R)-<(tert-butyldimethylsilyl)oxy>phenylacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-<(tert-butyldimethylsilyl)oxy>phenylacetic acid

There total 4 articles about (R)-<(tert-butyldimethylsilyl)oxy>phenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(R)-Mandelic Acid (611-71-2) + tert-butyldimethylsilyl chloride (18162-48-6) → (R)-<(tert-butyldimethylsilyl)oxy>phenylacetic acid (119619-48-6)

Guidance literature:

(R)-Mandelic Acid; tert-butyldimethylsilyl chloride; With 1H-imidazole; In tetrahydrofuran; at 4 - 20 ℃; for 4h;

With sodium hydroxide; for 1.75h;

DOI:10.1039/c3ob42515k

Reference yield:

(R)-tert-butyl(furan-2-yl(phenyl)methoxy)dimethylsilane → (R)-<(tert-butyldimethylsilyl)oxy>phenylacetic acid (119619-48-6)

Guidance literature:

With ozone; In methanol; at -78 ℃; for 2h; Yield given;

DOI:10.1021/jo00270a015

Reference yield:

2-furyl(phenyl)methanol (60907-91-7,113565-51-8,132435-41-7,4484-57-5) → (R)-<(tert-butyldimethylsilyl)oxy>phenylacetic acid (119619-48-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 38 percent

2: imidazole / dimethylformamide / 2 h / Ambient temperature

3: ozone / methanol / 2 h / -78 °C

With 1H-imidazole; ozone; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jo00270a015

upstream raw materials:

2-furyl(phenyl)methanol

(R)-2-furylphenylmethanol

(R)-Mandelic Acid

tert-butyldimethylsilyl chloride

Downstream raw materials:

C₃₂H₄₉NO₅Si₂

(R)-6-[(tert-butyldimethylsiloxy)phenylmethyl]-3-methoxy-2-phenylpyridin-4(1H)-one

(R)-6-[(tert-butyldimethylsiloxy)phenylmethyl]-3,4-dimethoxy-2-phenylpyridine

(R)-(4,5-dimethoxy-6-phenylpyridin-2-yl)phenylmethanol