((E)-(R)-5-((2S,3S)-3-Ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-3-hydroxy-3-{(4R,6R)-6-[(1Z,3Z)-4-((1R,3S)-3-hydroxy-cyclohexyl)-buta-1,3-dienyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-pent-4-enyl)-carbamic acid allyl ester

Base Information

Chemical Name:((E)-(R)-5-((2S,3S)-3-Ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-3-hydroxy-3-{(4R,6R)-6-[(1Z,3Z)-4-((1R,3S)-3-hydroxy-cyclohexyl)-buta-1,3-dienyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-pent-4-enyl)-carbamic acid allyl ester
CAS No.:467234-64-6
Molecular Formula:C₃₂H₄₇NO₈
Molecular Weight:573.727
Hs Code.:

((E)-(R)-5-((2S,3S)-3-Ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-3-hydroxy-3-{(4R,6R)-6-[(1Z,3Z)-4-((1R,3S)-3-hydroxy-cyclohexyl)-buta-1,3-dienyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-pent-4-enyl)-carbamic acid allyl ester

Synonyms:((E)-(R)-5-((2S,3S)-3-Ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-3-hydroxy-3-{(4R,6R)-6-[(1Z,3Z)-4-((1R,3S)-3-hydroxy-cyclohexyl)-buta-1,3-dienyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-pent-4-enyl)-carbamic acid allyl ester

Suppliers and Price of ((E)-(R)-5-((2S,3S)-3-Ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-3-hydroxy-3-{(4R,6R)-6-[(1Z,3Z)-4-((1R,3S)-3-hydroxy-cyclohexyl)-buta-1,3-dienyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-pent-4-enyl)-carbamic acid allyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ((E)-(R)-5-((2S,3S)-3-Ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-3-hydroxy-3-{(4R,6R)-6-[(1Z,3Z)-4-((1R,3S)-3-hydroxy-cyclohexyl)-buta-1,3-dienyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-pent-4-enyl)-carbamic acid allyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of ((E)-(R)-5-((2S,3S)-3-Ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-3-hydroxy-3-{(4R,6R)-6-[(1Z,3Z)-4-((1R,3S)-3-hydroxy-cyclohexyl)-buta-1,3-dienyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-pent-4-enyl)-carbamic acid allyl ester

There total 3 articles about ((E)-(R)-5-((2S,3S)-3-Ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-3-hydroxy-3-{(4R,6R)-6-[(1Z,3Z)-4-((1R,3S)-3-hydroxy-cyclohexyl)-buta-1,3-dienyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-pent-4-enyl)-carbamic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 77-76-9
2,2-dimethoxy-propane

: 467234-63-5
[(7Z,9Z)-(3R,4R,6R)-3-[(E)-2-((2S,3S)-3-Ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-vinyl]-3,4,6-trihydroxy-10-((1R,3S)-3-hydroxy-cyclohexyl)-deca-7,9-dienyl]-carbamic acid allyl ester

: 467234-64-6
((E)-(R)-5-((2S,3S)-3-Ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-3-hydroxy-3-{(4R,6R)-6-[(1Z,3Z)-4-((1R,3S)-3-hydroxy-cyclohexyl)-buta-1,3-dienyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-pent-4-enyl)-carbamic acid allyl ester

Guidance literature:: With 5A molecular sieve; pyridinium p-toluenesulfonate; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1016/S0040-4020(02)00528-8

Reference yield:

: leustroducsin-H

: 467234-64-6
((E)-(R)-5-((2S,3S)-3-Ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-3-hydroxy-3-{(4R,6R)-6-[(1Z,3Z)-4-((1R,3S)-3-hydroxy-cyclohexyl)-buta-1,3-dienyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-pent-4-enyl)-carbamic acid allyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 69 percent / NaHCO₃ / H₂O; dioxane / 2 h / 20 °C

2: 72 percent / alkaline phosphatase type-I / various solvent(s) / 48 h / 20 °C / pH 9.3 / Enzymatic reaction

3: 56 percent / molecular sieves 5 Angstroem; pyridinium p-toluenesulfonate / CH₂Cl₂ / 16 h / 20 °C

With 5A molecular sieve; alkaline phosphatase type-I; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/S0040-4020(02)00528-8

Reference yield:

: 685530-39-6
[(7Z,9Z)-(3R,4R,6R)-3-[(E)-2-((2S,3S)-3-Ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-vinyl]-3,6-dihydroxy-10-((1R,3S)-3-hydroxy-cyclohexyl)-4-phosphonooxy-deca-7,9-dienyl]-carbamic acid allyl ester

: 467234-64-6
((E)-(R)-5-((2S,3S)-3-Ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-3-hydroxy-3-{(4R,6R)-6-[(1Z,3Z)-4-((1R,3S)-3-hydroxy-cyclohexyl)-buta-1,3-dienyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-pent-4-enyl)-carbamic acid allyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / alkaline phosphatase type-I / various solvent(s) / 48 h / 20 °C / pH 9.3 / Enzymatic reaction

2: 56 percent / molecular sieves 5 Angstroem; pyridinium p-toluenesulfonate / CH₂Cl₂ / 16 h / 20 °C

With 5A molecular sieve; alkaline phosphatase type-I; pyridinium p-toluenesulfonate; In dichloromethane;
DOI:10.1016/S0040-4020(02)00528-8