Technology Process of methyl 2-[2,6-bis(methoxymethoxy)-3,5-dichloro-4-methylbenzoyl]-3-methoxy-5-(methoxymethoxy)benzoate
There total 18 articles about methyl 2-[2,6-bis(methoxymethoxy)-3,5-dichloro-4-methylbenzoyl]-3-methoxy-5-(methoxymethoxy)benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 95 percent / NaH / dimethylformamide / 1 h / 0 - 20 °C
2: 95 percent / n-BuLi / hexane; diethyl ether / 3 h / -78 - 20 °C
3: 94 percent / aq. HCl / tetrahydrofuran / 2 h / 20 °C
4: 72 percent / K2CO3 / acetone / 1 h / 20 °C
5: 90 percent / Cs2CO3 / dimethylformamide / 1 h / 20 °C
6: 86 percent / n-BuLi / tetrahydrofuran; hexane / 3.25 h / -78 - 20 °C
7: 98 percent / Dess-Martin periodinane / CH2Cl2 / 0.75 h / 20 °C
8: 79 percent / H2 / Pd/C / ethanol / 1 h / 20 °C / 760 Torr
9: 95 percent / Dess-Martin periodinane / CH2Cl2 / 1 h / 20 °C
10: aq. NaH2PO4; NaClO2; 2-methyl-2-butene / tetrahydrofuran; 2-methyl-propan-2-ol / 1 h / 20 °C
11: 203 mg / diethyl ether; methanol / 0.17 h / 20 °C
With
hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; 2-methyl-but-2-ene; hydrogen; sodium hydride; potassium carbonate; caesium carbonate; Dess-Martin periodane;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;
7: Dess-Martin oxidation / 9: Dess-Martin oxidation;
DOI:10.1016/S0040-4020(01)01250-9
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 88 percent / Br2 / CH2Cl2; dimethylformamide / 3 h / 20 °C
2: 100 percent / DIPEA / CH2Cl2 / 1 h / 20 °C
3: 86 percent / n-BuLi / tetrahydrofuran; hexane / 3.25 h / -78 - 20 °C
4: 98 percent / Dess-Martin periodinane / CH2Cl2 / 0.75 h / 20 °C
5: 79 percent / H2 / Pd/C / ethanol / 1 h / 20 °C / 760 Torr
6: 95 percent / Dess-Martin periodinane / CH2Cl2 / 1 h / 20 °C
7: aq. NaH2PO4; NaClO2; 2-methyl-2-butene / tetrahydrofuran; 2-methyl-propan-2-ol / 1 h / 20 °C
8: 203 mg / diethyl ether; methanol / 0.17 h / 20 °C
With
sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; 2-methyl-but-2-ene; hydrogen; bromine; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
4: Dess-Martin oxidation / 6: Dess-Martin oxidation;
DOI:10.1016/S0040-4020(01)01250-9
- Guidance literature:
-
Multi-step reaction with 12 steps
1: 93 percent / N-bromosuccinimide / dimethylformamide / 2 h / 0 °C
2: 95 percent / NaH / dimethylformamide / 1 h / 0 - 20 °C
3: 95 percent / n-BuLi / hexane; diethyl ether / 3 h / -78 - 20 °C
4: 94 percent / aq. HCl / tetrahydrofuran / 2 h / 20 °C
5: 72 percent / K2CO3 / acetone / 1 h / 20 °C
6: 90 percent / Cs2CO3 / dimethylformamide / 1 h / 20 °C
7: 86 percent / n-BuLi / tetrahydrofuran; hexane / 3.25 h / -78 - 20 °C
8: 98 percent / Dess-Martin periodinane / CH2Cl2 / 0.75 h / 20 °C
9: 79 percent / H2 / Pd/C / ethanol / 1 h / 20 °C / 760 Torr
10: 95 percent / Dess-Martin periodinane / CH2Cl2 / 1 h / 20 °C
11: aq. NaH2PO4; NaClO2; 2-methyl-2-butene / tetrahydrofuran; 2-methyl-propan-2-ol / 1 h / 20 °C
12: 203 mg / diethyl ether; methanol / 0.17 h / 20 °C
With
hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; N-Bromosuccinimide; n-butyllithium; 2-methyl-but-2-ene; hydrogen; sodium hydride; potassium carbonate; caesium carbonate; Dess-Martin periodane;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;
8: Dess-Martin oxidation / 10: Dess-Martin oxidation;
DOI:10.1016/S0040-4020(01)01250-9