2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid 1-methylpropyl ester

Base Information

Chemical Name:2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid 1-methylpropyl ester
CAS No.:1363896-50-7
Molecular Formula:C₄₀H₄₇FN₂O₅
Molecular Weight:654.822
Hs Code.:

2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid 1-methylpropyl ester

Synonyms:2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid 1-methylpropyl ester

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Chemical Property of 2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid 1-methylpropyl ester

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Technology Process of 2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid 1-methylpropyl ester

There total 4 articles about 2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid 1-methylpropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1363896-48-3
(4R,6R)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid 1-methylpropyl ester

: 125971-96-2,125971-58-6
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

: 1363896-50-7
2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid 1-methylpropyl ester

Guidance literature:: With Trimethylacetic acid; In tetrahydrofuran; n-heptane; Reflux;

Reference yield:

: 77-76-9
2,2-dimethoxy-propane

: 1363896-50-7
2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid 1-methylpropyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / water / 25 - 30 °C

1.2: 60 - 70 °C / Azeotropic distillation of water

1.3: 1 h / 25 °C

2.1: hydrogen / Raney cobalt / iso-butanol / 77 h / 50 °C / 9000.9 Torr / Inert atmosphere

3.1: Trimethylacetic acid / n-heptane; tetrahydrofuran / 48 h / Reflux; Azeotropic distillation of water

With hydrogen; sodium hydroxide; Trimethylacetic acid; Raney cobalt; In tetrahydrofuran; n-heptane; water; iso-butanol;

Reference yield:

: 1363896-30-3
(4R,6R)-6-(2-cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid 1-methylpropyl-ester

: 1363896-50-7
2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid 1-methylpropyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / Raney cobalt / iso-butanol / 77 h / 50 °C / 9000.9 Torr / Inert atmosphere

2: Trimethylacetic acid / n-heptane; tetrahydrofuran / 48 h / Reflux; Azeotropic distillation of water

With hydrogen; Trimethylacetic acid; Raney cobalt; In tetrahydrofuran; n-heptane; iso-butanol;