di-tert-butyl 2,2'-(4-(2-aminoethyl)-10-(2-oxo-2-(2-(trifluoromethyl)phenylamino)ethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate

Base Information

Chemical Name:di-tert-butyl 2,2'-(4-(2-aminoethyl)-10-(2-oxo-2-(2-(trifluoromethyl)phenylamino)ethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate
CAS No.:1402393-81-0
Molecular Formula:C₃₁H₅₁F₃N₆O₅
Molecular Weight:644.778
Hs Code.:

Synonyms:di-tert-butyl 2,2'-(4-(2-aminoethyl)-10-(2-oxo-2-(2-(trifluoromethyl)phenylamino)ethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate

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Chemical Property of di-tert-butyl 2,2'-(4-(2-aminoethyl)-10-(2-oxo-2-(2-(trifluoromethyl)phenylamino)ethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate

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Technology Process of di-tert-butyl 2,2'-(4-(2-aminoethyl)-10-(2-oxo-2-(2-(trifluoromethyl)phenylamino)ethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate

There total 4 articles about di-tert-butyl 2,2'-(4-(2-aminoethyl)-10-(2-oxo-2-(2-(trifluoromethyl)phenylamino)ethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1402393-80-9
di-tert-butyl 2,2'-(4-(2-(benzyloxycarbonylamino)ethyl)-10-(2-oxo-2-(2-(trifluoromethyl)phenylamino)ethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate

: 1402393-81-0
di-tert-butyl 2,2'-(4-(2-aminoethyl)-10-(2-oxo-2-(2-(trifluoromethyl)phenylamino)ethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 8h; under 2068.65 Torr;
DOI:10.1002/chem.201200737

Reference yield:

: 162148-48-3
(7-tert-butoxycarbonylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl)-acetic acid tert-butyl ester

: 1402393-81-0
di-tert-butyl 2,2'-(4-(2-aminoethyl)-10-(2-oxo-2-(2-(trifluoromethyl)phenylamino)ethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

1.2: 80 °C / Inert atmosphere

2.1: potassium carbonate / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere; Reflux

3.1: palladium 10% on activated carbon; hydrogen / methanol / 8 h / 20 °C / 2068.65 Torr

With palladium 10% on activated carbon; hydrogen; sodium carbonate; potassium carbonate; In methanol; acetonitrile;
DOI:10.1002/chem.201200737

Reference yield:

: 3792-04-9
2-chloro-N-[2-(trifluoromethyl)phenyl]acetamide

: 1402393-81-0
di-tert-butyl 2,2'-(4-(2-aminoethyl)-10-(2-oxo-2-(2-(trifluoromethyl)phenylamino)ethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

1.2: 80 °C / Inert atmosphere

2.1: potassium carbonate / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere; Reflux

3.1: palladium 10% on activated carbon; hydrogen / methanol / 8 h / 20 °C / 2068.65 Torr

With palladium 10% on activated carbon; hydrogen; sodium carbonate; potassium carbonate; In methanol; acetonitrile;
DOI:10.1002/chem.201200737