Butanoic acid, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-YL)oxy]-3-methyl-, 1,1-dimethylethyl ester, (2R)-

Base Information

Chemical Name:Butanoic acid, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-YL)oxy]-3-methyl-, 1,1-dimethylethyl ester, (2R)-
CAS No.:380886-38-4
Molecular Formula:C₁₇H₂₁NO₅
Molecular Weight:319.357
Hs Code.:
DSSTox Substance ID:DTXSID201123908
Nikkaji Number:J1.660.783E
Mol file:380886-38-4.mol

Synonyms:380886-38-4;BUTANOIC ACID, 2-[(1,3-DIHYDRO-1,3-DIOXO-2H-ISOINDOL-2-YL)OXY]-3-METHYL-, 1,1-DIMETHYLETHYL ESTER, (2R)-;Butanoic acid,2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-3-methyl-,1,1-dimethylethyl ester,(2R)-;DTXSID201123908;(R)-2-(Phthalimidyloxy)-3-methylbutanoic acid tert-butyl ester;1,1-Dimethylethyl (2R)-2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-3-methylbutanoate

Suppliers and Price of Butanoic acid, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-YL)oxy]-3-methyl-, 1,1-dimethylethyl ester, (2R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(2R)-2-[(1,3-DIHYDRO-1,3-DIOXO-2H-ISOINDOL-2-YL)OXY]-3-METHYL-BUTANOIC ACID-1,1-DIMETHYLETHYL ESTER 95.00%
5MG
$ 502.62

Total 5 raw suppliers

Chemical Property of Butanoic acid, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-YL)oxy]-3-methyl-, 1,1-dimethylethyl ester, (2R)-

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.547
Boiling Point:416.922°C at 760 mmHg
Flash Point:205.947°C
PSA：72.91000
Density:1.217g/cm³
LogP:2.51840
XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:319.14197277
Heavy Atom Count:23
Complexity:470

Purity/Quality:

98% ^*data from raw suppliers

(2R)-2-[(1,3-DIHYDRO-1,3-DIOXO-2H-ISOINDOL-2-YL)OXY]-3-METHYL-BUTANOIC ACID-1,1-DIMETHYLETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)C(C(=O)OC(C)(C)C)ON1C(=O)C2=CC=CC=C2C1=O
Isomeric SMILES:CC(C)[C@H](C(=O)OC(C)(C)C)ON1C(=O)C2=CC=CC=C2C1=O

Technology Process of Butanoic acid, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-YL)oxy]-3-methyl-, 1,1-dimethylethyl ester, (2R)-

There total 5 articles about Butanoic acid, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-YL)oxy]-3-methyl-, 1,1-dimethylethyl ester, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 524-38-9
N-hydroxyphthalimide

: 3519-30-0
L-α-hydroxyisovaleric acid t-butyl ester

: 380886-38-4
D-tert-butyl 2-phthalimid-N-oxy-3-methylbutanoate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;
DOI:10.1021/jo010376a

Reference yield:

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 380886-38-4
D-tert-butyl 2-phthalimid-N-oxy-3-methylbutanoate

Guidance literature:: Multi-step reaction with 5 steps

1: aq. HCl; NaNO₂ / 6 h / 0 °C

2: 4 h / 60 °C

3: DMAP; DCC / CH₂Cl₂ / 12 h / 20 °C

4: K₂CO₃ / methanol; H₂O / 12 h / 20 °C

5: 75 percent / DEAD; PPh₃ / tetrahydrofuran

With hydrogenchloride; dmap; potassium carbonate; dicyclohexyl-carbodiimide; triphenylphosphine; sodium nitrite; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jo010376a

Reference yield:

: 17407-55-5
(S)-2-Hydroxy-3-methylbutanoic acid

: 380886-38-4
D-tert-butyl 2-phthalimid-N-oxy-3-methylbutanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 4 h / 60 °C

2: DMAP; DCC / CH₂Cl₂ / 12 h / 20 °C

3: K₂CO₃ / methanol; H₂O / 12 h / 20 °C

4: 75 percent / DEAD; PPh₃ / tetrahydrofuran

With dmap; potassium carbonate; dicyclohexyl-carbodiimide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jo010376a