(R)-tert-Butyl 2-(1,3-dioxoisoindolin-2-yloxy)-3-phenylpropanoate

Base Information

Chemical Name:(R)-tert-Butyl 2-(1,3-dioxoisoindolin-2-yloxy)-3-phenylpropanoate
CAS No.:380886-37-3
Molecular Formula:C21H21 N O5
Molecular Weight:367.4
Hs Code.:
DSSTox Substance ID:DTXSID701125535
Nikkaji Number:J1.660.782G
Mol file:380886-37-3.mol

Synonyms:380886-37-3;(R)-tert-Butyl 2-(1,3-dioxoisoindolin-2-yloxy)-3-phenylpropanoate;tert-butyl (2R)-2-(1,3-dioxoisoindol-2-yl)oxy-3-phenylpropanoate;Benzenepropanoic acid,a-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-,1,1-dimethylethyl ester,(aR)-;Benzenepropanoicacid,a-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-,1,1-dimethylethylester,(aR)-;BENZENEPROPANOIC ACID,A-[(1,3-DIHYDRO-1,3-DIOXO-2H-ISOINDOL-2-YL)OXY]-, 1,1-DIMETHYLETHYL ESTER, (AR)-;SCHEMBL13765053;DTXSID701125535;CS-B0162;AKOS037649968;CS-13972;1,1-Dimethylethyl (alphaR)-alpha-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]benzenepropanoate;Benzenepropanoic acid,-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-, 1,1-dimethylethyl ester, (R)-

Suppliers and Price of (R)-tert-Butyl 2-(1,3-dioxoisoindolin-2-yloxy)-3-phenylpropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
Benzenepropanoicacid,α-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-,1,1-dimethylethylester,(αR)-
250mg
$ 197.00

American Custom Chemicals Corporation
(ALPHA R)-ALPHA-[(1,3-DIHYDRO-1,3-DIOXO-2H-ISOINDOL-2-YL)OXY]BENZENEPROPANOIC ACID-1,1-DIMETHYLETHYL ESTER 95.00%
5MG
$ 498.41

Total 12 raw suppliers

Chemical Property of (R)-tert-Butyl 2-(1,3-dioxoisoindolin-2-yloxy)-3-phenylpropanoate

Chemical Property:

Boiling Point:506.3±60.0 °C(Predicted)
PSA：72.91000
Density:1.27±0.1 g/cm3(Predicted)
LogP:3.10510
XLogP3:3.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:367.14197277
Heavy Atom Count:27
Complexity:552

Purity/Quality:

NLT 98% ^*data from raw suppliers

Benzenepropanoicacid,α-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-,1,1-dimethylethylester,(αR)- ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)C(CC1=CC=CC=C1)ON2C(=O)C3=CC=CC=C3C2=O
Isomeric SMILES:CC(C)(C)OC(=O)[C@@H](CC1=CC=CC=C1)ON2C(=O)C3=CC=CC=C3C2=O

Technology Process of (R)-tert-Butyl 2-(1,3-dioxoisoindolin-2-yloxy)-3-phenylpropanoate

There total 5 articles about (R)-tert-Butyl 2-(1,3-dioxoisoindolin-2-yloxy)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 524-38-9
N-hydroxyphthalimide

: 7622-23-3
L-α-hydroxyhydrocinnamic acid t-butyl ester

: 380886-37-3
D-tert-butyl 2-phthalimid-N-oxy-3-phenylpropanoate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;
DOI:10.1021/jo010376a

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 380886-37-3
D-tert-butyl 2-phthalimid-N-oxy-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 58 percent / aq. HCl; NaNO₂ / 6 h / 0 °C

2: 2.43 g / 4 h / 60 °C

3: 81 percent / DMAP; DCC / CH₂Cl₂ / 12 h / 20 °C

4: 89 percent / K₂CO₃ / methanol; H₂O / 12 h / 20 °C

5: 89 percent / DEAD; PPh₃ / tetrahydrofuran

With hydrogenchloride; dmap; potassium carbonate; dicyclohexyl-carbodiimide; triphenylphosphine; sodium nitrite; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jo010376a

Reference yield:

: 20312-36-1
L-3-phenyllactic acid

: 380886-37-3
D-tert-butyl 2-phthalimid-N-oxy-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 2.43 g / 4 h / 60 °C

2: 81 percent / DMAP; DCC / CH₂Cl₂ / 12 h / 20 °C

3: 89 percent / K₂CO₃ / methanol; H₂O / 12 h / 20 °C

4: 89 percent / DEAD; PPh₃ / tetrahydrofuran

With dmap; potassium carbonate; dicyclohexyl-carbodiimide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jo010376a