N-{6-amino-5-[2-(trifluoromethoxy)phenyl]pyrazin-2-yl}-5-(methoxymethyl)isoxazole-4-carboxamide

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Chemical Name:N-{6-amino-5-[2-(trifluoromethoxy)phenyl]pyrazin-2-yl}-5-(methoxymethyl)isoxazole-4-carboxamide
CAS No.:1076245-65-2
Molecular Formula:C₁₇H₁₄F₃N₅O₄
Molecular Weight:409.324
Hs Code.:

Synonyms:N-{6-amino-5-[2-(trifluoromethoxy)phenyl]pyrazin-2-yl}-5-(methoxymethyl)isoxazole-4-carboxamide

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Chemical Property of N-{6-amino-5-[2-(trifluoromethoxy)phenyl]pyrazin-2-yl}-5-(methoxymethyl)isoxazole-4-carboxamide

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Technology Process of N-{6-amino-5-[2-(trifluoromethoxy)phenyl]pyrazin-2-yl}-5-(methoxymethyl)isoxazole-4-carboxamide

There total 4 articles about N-{6-amino-5-[2-(trifluoromethoxy)phenyl]pyrazin-2-yl}-5-(methoxymethyl)isoxazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1076245-79-8
3-[2-(trifluoromethoxy)phenyl]pyrazine-2,6-diamine

: 134541-08-5
5-(methoxymethyl)isoxazole-4-carboxylic acid

: 1076245-65-2
N-{6-amino-5-[2-(trifluoromethoxy)phenyl]pyrazin-2-yl}-5-(methoxymethyl)isoxazole-4-carboxamide

Guidance literature:: 5-(methoxymethyl)isoxazole-4-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 3.5h;

3-[2-(trifluoromethoxy)phenyl]pyrazine-2,6-diamine; With lutidine; In acetonitrile; at 20 ℃; for 36h;

Reference yield:

: 175676-65-0
2-trifluoromethoxyphenylboronic acid

: 1076245-65-2
N-{6-amino-5-[2-(trifluoromethoxy)phenyl]pyrazin-2-yl}-5-(methoxymethyl)isoxazole-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 4 h / 75 °C

2.1: lithium hydroxide; water / methanol / 1 h / 90 °C

2.2: 1.5 h / 100 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3.5 h / 20 °C

3.2: lutidine / 36 h / 20 °C

With lithium hydroxide; oxalyl dichloride; water; caesium carbonate; N,N-dimethyl-formamide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; dichloromethane; water; 1.1: Suzuki Coupling;

Reference yield:

: 41051-15-4
4-methoxyacetoacetic acid methylester

: 1076245-65-2
N-{6-amino-5-[2-(trifluoromethoxy)phenyl]pyrazin-2-yl}-5-(methoxymethyl)isoxazole-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 20 h / 20 - 90 °C

2.1: hydroxylamine hydrochloride / methanol / 7 h / Heating / reflux

3.1: hydrogenchloride; water; acetic acid / 6 h / Heating / reflux

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3.5 h / 20 °C

4.2: lutidine / 36 h / 20 °C

With hydrogenchloride; oxalyl dichloride; hydroxylamine hydrochloride; water; acetic acid; N,N-dimethyl-formamide; In methanol; dichloromethane;