(1R,4R)-5-(4-hydroxy-benzenesulfonyl)-8,8-dimethyl-2-oxa-5-aza-bicyclo[2.2.2]octan-3-one

Base Information

Chemical Name:(1R,4R)-5-(4-hydroxy-benzenesulfonyl)-8,8-dimethyl-2-oxa-5-aza-bicyclo[2.2.2]octan-3-one
CAS No.:329041-30-7
Molecular Formula:C₁₄H₁₇NO₅S
Molecular Weight:311.359
Hs Code.:

Synonyms:(1R,4R)-5-(4-hydroxy-benzenesulfonyl)-8,8-dimethyl-2-oxa-5-aza-bicyclo[2.2.2]octan-3-one

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Chemical Property of (1R,4R)-5-(4-hydroxy-benzenesulfonyl)-8,8-dimethyl-2-oxa-5-aza-bicyclo[2.2.2]octan-3-one

Chemical Property:

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Technology Process of (1R,4R)-5-(4-hydroxy-benzenesulfonyl)-8,8-dimethyl-2-oxa-5-aza-bicyclo[2.2.2]octan-3-one

There total 6 articles about (1R,4R)-5-(4-hydroxy-benzenesulfonyl)-8,8-dimethyl-2-oxa-5-aza-bicyclo[2.2.2]octan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 329041-29-4
(1 R ,4 R)-5-(4-Benzyloxy-benzenesulfonyl)-8,8-dimethyl-2-oxa-5-aza-bicyclo[2.2.2]octan-3-one

: 329041-30-7
(1R,4R)-5-(4-hydroxy-benzenesulfonyl)-8,8-dimethyl-2-oxa-5-aza-bicyclo[2.2.2]octan-3-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1016/j.bmcl.2005.03.105

Reference yield:

: 329041-24-9
(2R)-3,3-dimethyl-2-(1-(R)-phenyl-ethylamino)-hex-5-enenitrile

: 329041-30-7
(1R,4R)-5-(4-hydroxy-benzenesulfonyl)-8,8-dimethyl-2-oxa-5-aza-bicyclo[2.2.2]octan-3-one

Guidance literature:: Multi-step reaction with 6 steps

1: 73 percent / DHQD-PHN; K₃Fe(CN)6; K₂CO₃ / 2-methyl-propan-2-ol; H₂O

2: 97 percent / aq. HCl / Heating

3: 78 percent / TsCl; pyridine / 20 °C

4: 36 percent / H₂ / Pd/C / methanol

5: Et₃N / CH₂Cl₂

6: H₂ / Pd/C / methanol

With pyridine; hydrogenchloride; hydrogen; potassium carbonate; 9-O-(9'-phenanthryl) ether of dihydroquinidine; triethylamine; p-toluenesulfonyl chloride; potassium hexacyanoferrate(III); palladium on activated charcoal; In methanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2005.03.105

Reference yield:

: 329041-27-2
(1R,4R)-8,8-Dimethyl-5-((R)-1-phenyl-ethyl)-2-oxa-5-aza-bicyclo[2.2.2]octan-3-one

: 329041-30-7
(1R,4R)-5-(4-hydroxy-benzenesulfonyl)-8,8-dimethyl-2-oxa-5-aza-bicyclo[2.2.2]octan-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: 36 percent / H₂ / Pd/C / methanol

2: Et₃N / CH₂Cl₂

3: H₂ / Pd/C / methanol

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2005.03.105