1-dimethylsilyl-4-deacetyl-4-acryloyl-7-O,10-O,13-O-tris-triethylsilylbaccatin III

Base Information

Chemical Name:1-dimethylsilyl-4-deacetyl-4-acryloyl-7-O,10-O,13-O-tris-triethylsilylbaccatin III
CAS No.:860782-19-0
Molecular Formula:C₅₀H₈₄O₁₀Si₄
Molecular Weight:957.553
Hs Code.:

Synonyms:1-dimethylsilyl-4-deacetyl-4-acryloyl-7-O,10-O,13-O-tris-triethylsilylbaccatin III

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-dimethylsilyl-4-deacetyl-4-acryloyl-7-O,10-O,13-O-tris-triethylsilylbaccatin III

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Technology Process of 1-dimethylsilyl-4-deacetyl-4-acryloyl-7-O,10-O,13-O-tris-triethylsilylbaccatin III

There total 1 articles about 1-dimethylsilyl-4-deacetyl-4-acryloyl-7-O,10-O,13-O-tris-triethylsilylbaccatin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 814-68-6,25189-84-8
acryloyl chloride

: 1-dimethylsilyl-7,10,13-tris(triethylsilyl)-4,10-deacetyl-4-hydroxybaccatin III

: 860782-19-0
1-dimethylsilyl-4-deacetyl-4-acryloyl-7-O,10-O,13-O-tris-triethylsilylbaccatin III

Guidance literature:: 1-dimethylsilyl-7,10,13-tris(triethylsilyl)-4,10-deacetyl-4-hydroxybaccatin III; With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 0.75h;

acryloyl chloride; In tetrahydrofuran; at 0 ℃; for 3h;
DOI:10.1021/jm061071x

Reference yield: 70.0%

: 860782-19-0
1-dimethylsilyl-4-deacetyl-4-acryloyl-7-O,10-O,13-O-tris-triethylsilylbaccatin III

: 860782-20-3
4-deacetyl-4-acryloyl-10-deacetylbaccatin III

Guidance literature:: With pyridine hydrogenfluoride; In tetrahydrofuran; at 0 - 20 ℃; for 24h;
DOI:10.1021/jm061071x

Reference yield:

: 860782-19-0
1-dimethylsilyl-4-deacetyl-4-acryloyl-7-O,10-O,13-O-tris-triethylsilylbaccatin III

: 757977-17-6
C₄₉H₅₁NO₁₄

Guidance literature:: Multi-step reaction with 6 steps

1: 70 percent / HF*pyridine / tetrahydrofuran / 24 h / 0 - 20 °C

2: 96 percent / CeCl₃ / tetrahydrofuran / 4 h

3: 72 percent / imidazole / CH₂Cl₂ / 3 h / 0 °C

4: 87 percent / lithium hexamethyldisilazide / tetrahydrofuran / 3 h / -40 °C

5: 87 percent / (H₂IMes)(PCy₃)(Cl)2Ru=CHPh / CH₂Cl₂ / 20 °C

6: 77 percent / HF*pyridine / tetrahydrofuran / 0 - 20 °C

With 1H-imidazole; cerium(III) chloride; pyridine hydrogenfluoride; lithium hexamethyldisilazane; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm061071x