Technology Process of 1-dimethylsilyl-4-deacetyl-4-acryloyl-7-O,10-O,13-O-tris-triethylsilylbaccatin III
There total 1 articles about 1-dimethylsilyl-4-deacetyl-4-acryloyl-7-O,10-O,13-O-tris-triethylsilylbaccatin III which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-dimethylsilyl-7,10,13-tris(triethylsilyl)-4,10-deacetyl-4-hydroxybaccatin III;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran;
at 0 ℃;
for 0.75h;
acryloyl chloride;
In
tetrahydrofuran;
at 0 ℃;
for 3h;
DOI:10.1021/jm061071x
- Guidance literature:
-
With
pyridine hydrogenfluoride;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 24h;
DOI:10.1021/jm061071x
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 70 percent / HF*pyridine / tetrahydrofuran / 24 h / 0 - 20 °C
2: 96 percent / CeCl3 / tetrahydrofuran / 4 h
3: 72 percent / imidazole / CH2Cl2 / 3 h / 0 °C
4: 87 percent / lithium hexamethyldisilazide / tetrahydrofuran / 3 h / -40 °C
5: 87 percent / (H2IMes)(PCy3)(Cl)2Ru=CHPh / CH2Cl2 / 20 °C
6: 77 percent / HF*pyridine / tetrahydrofuran / 0 - 20 °C
With
1H-imidazole; cerium(III) chloride; pyridine hydrogenfluoride; lithium hexamethyldisilazane;
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jm061071x
