757977-17-6Relevant articles and documents
Evaluation of the tubulin-bound paclitaxel conformation: Synthesis, biology, and SAR studies of C-4 to C-3′ bridged paclitaxel analogues
Ganesh, Thota,Yang, Chao,Norris, Andrew,Glass, Tom,Bane, Susan,Ravindra, Rudravajhala,Banerjee, Abhijit,Metaferia, Belhu,Thomas, Shala L.,Giannakakou, Paraskevi,Alcaraz, Ana A.,Lakdawala, Ami S.,Snyder, James P.,Kingston, David G. I.
, p. 713 - 725 (2007/10/03)
The important anticancer drug paclitaxel binds to the β-subunit of the ββ-tubulin dimer in the microtubule in a stoichiometric ratio, promoting microtubule polymerization and stability. The conformation of microtubule-bound drug has been the subject of in
CONFORMATIONALLY CONSTRAINED PACLITAXEL ANALOGS AND THEIR USE AS ANTICANCER AND ANTI-ALZHEIMERS AGENTS
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Page/Page column Fig. 8A; Fig. 12; 7; 32-33, (2010/02/13)
Constrained paclitaxel derivatives include a bridge extending from the C-3’ phenyl to either the C4 or -3 positions. Many of the constrained paclitaxel derivatives provide activity comparable or superior to the natural product paclitaxel.