5-[4-[2-(2-trimethylsilylethoxymethyl)pyrazol-3-yl]phenoxy]pyridin-2-amine

Base Information

Chemical Name:5-[4-[2-(2-trimethylsilylethoxymethyl)pyrazol-3-yl]phenoxy]pyridin-2-amine
CAS No.:1541188-29-7
Molecular Formula:C₂₀H₂₆N₄O₂Si
Molecular Weight:382.538
Hs Code.:

Synonyms:5-[4-[2-(2-trimethylsilylethoxymethyl)pyrazol-3-yl]phenoxy]pyridin-2-amine

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Chemical Property of 5-[4-[2-(2-trimethylsilylethoxymethyl)pyrazol-3-yl]phenoxy]pyridin-2-amine

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Technology Process of 5-[4-[2-(2-trimethylsilylethoxymethyl)pyrazol-3-yl]phenoxy]pyridin-2-amine

There total 4 articles about 5-[4-[2-(2-trimethylsilylethoxymethyl)pyrazol-3-yl]phenoxy]pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₂₄N₄O₄Si

: 1541188-29-7
5-[4-[2-(2-trimethylsilylethoxymethyl)pyrazol-3-yl]phenoxy]pyridin-2-amine

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; for 3h;

Reference yield:

: 1419211-50-9
4-[2-(2-trimethylsilanyl-ethoxymethyl)-2H-pyrazol-3-yl]-phenol

: 1541188-29-7
5-[4-[2-(2-trimethylsilylethoxymethyl)pyrazol-3-yl]phenoxy]pyridin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.33 h / Inert atmosphere

1.2: 2 h / 60 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h

With palladium 10% on activated carbon; hydrogen; caesium carbonate; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 903550-12-9
5-(4,4,5,5-tetramethyl-[1,3 ,2]dioxaborolan-2-yl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazole

: 1541188-29-7
5-[4-[2-(2-trimethylsilylethoxymethyl)pyrazol-3-yl]phenoxy]pyridin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 16 h / 100 °C / Inert atmosphere

2.1: caesium carbonate / N,N-dimethyl-formamide / 0.33 h / Inert atmosphere

2.2: 2 h / 60 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium carbonate; caesium carbonate; In methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;