N⁽¹⁾-(4-butylphenyl)-N⁽¹⁾,N⁽²⁾-dimethyl-N⁽²⁾-(3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)phthalamide

Base Information

• Chemical Name: N⁽¹⁾-(4-butylphenyl)-N⁽¹⁾,N⁽²⁾-dimethyl-N⁽²⁾-(3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)phthalamide
• CAS No.: 1361226-03-0
• Molecular Formula: C₃₂H₃₈N₂O₄
• Molecular Weight: 514.665
• Mol file: 1361226-03-0.mol

Synonyms:N⁽¹⁾-(4-butylphenyl)-N⁽¹⁾,N⁽²⁾-dimethyl-N⁽²⁾-(3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)phthalamide

Chemical Property of N⁽¹⁾-(4-butylphenyl)-N⁽¹⁾,N⁽²⁾-dimethyl-N⁽²⁾-(3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)phthalamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁽¹⁾-(4-butylphenyl)-N⁽¹⁾,N⁽²⁾-dimethyl-N⁽²⁾-(3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)phthalamide

There total 1 articles about N⁽¹⁾-(4-butylphenyl)-N⁽¹⁾,N⁽²⁾-dimethyl-N⁽²⁾-(3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)phthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N(1)-(4-butylphenyl)-N(2)-(3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)phthalamide (1361226-02-9) + methyl iodide (74-88-4) → N(1)-(4-butylphenyl)-N(1),N(2)-dimethyl-N(2)-(3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)phthalamide (1361226-03-0)

Guidance literature:

N⁽¹⁾-(4-butylphenyl)-N⁽²⁾-(3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)phthalamide; With sodium hydride; In N,N-dimethyl-formamide; for 0.25h; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201102018

Reference yield: 84.0%

N(1)-(4-butylphenyl)-N(1),N(2)-dimethyl-N(2)-(3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)phthalamide (1361226-03-0) → N(1)-(4-butylphenyl)-N(2)-(3-(hydroxymethyl)phenyl)-N(1),N(2)-dimethylphthalamide (1361226-21-2)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; at 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201102018

Reference yield:

N(1)-(4-butylphenyl)-N(1),N(2)-dimethyl-N(2)-(3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)phthalamide (1361226-03-0) → N(1)-(4-butylphenyl)-N(2)-(3-(((11bS)-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yloxy)methyl)phenyl)-N(1),N(2)-dimethylphthalamide

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / methanol / 20 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere

With toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol;

DOI:10.1002/chem.201102018

upstream raw materials:

N⁽¹⁾-(4-butylphenyl)-N⁽²⁾-(3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)phthalamide

methyl iodide

Downstream raw materials:

N⁽¹⁾-(4-butylphenyl)-N⁽²⁾-(3-(hydroxymethyl)phenyl)-N⁽¹⁾,N⁽²⁾-dimethylphthalamide