N-benzyloxy-2-[(4-chloro-benzyl)-(3-trifluoromethyl-benzenesulfonyl)-amino]-3-phenyl-propionamide

Base Information

Chemical Name:N-benzyloxy-2-[(4-chloro-benzyl)-(3-trifluoromethyl-benzenesulfonyl)-amino]-3-phenyl-propionamide
CAS No.:245365-19-9
Molecular Formula:C₃₀H₂₆ClF₃N₂O₄S
Molecular Weight:603.062
Hs Code.:

<i>N</i>-benzyloxy-2-[(4-chloro-benzyl)-(3-trifluoromethyl-benzenesulfonyl)-amino]-3-phenyl-propionamide

Synonyms:N-benzyloxy-2-[(4-chloro-benzyl)-(3-trifluoromethyl-benzenesulfonyl)-amino]-3-phenyl-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-benzyloxy-2-[(4-chloro-benzyl)-(3-trifluoromethyl-benzenesulfonyl)-amino]-3-phenyl-propionamide

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Technology Process of N-benzyloxy-2-[(4-chloro-benzyl)-(3-trifluoromethyl-benzenesulfonyl)-amino]-3-phenyl-propionamide

There total 4 articles about N-benzyloxy-2-[(4-chloro-benzyl)-(3-trifluoromethyl-benzenesulfonyl)-amino]-3-phenyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15100-75-1,75898-47-4
L-phenylalanine tert-butyl ester hydrochloride

: 245365-19-9
N-benzyloxy-2-[(4-chloro-benzyl)-(3-trifluoromethyl-benzenesulfonyl)-amino]-3-phenyl-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / pyridine

2: 100 percent / polymer-supported phosphazene - BEMP on polystyrene / CH₂Cl₂

3: TFA / CH₂Cl₂

4: CBr₄, NEt₃, polymer-supported triphenylphosphine / CH₂Cl₂

With pyridine; polystyrene-bound 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; PS-triphenylphosphine; carbon tetrabromide; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0960-894X(99)00311-X

Reference yield:

: 245364-66-3
3-phenyl-2-(3-trifluoromethyl-benzenesulfonylamino)-propionic acid tert-butyl ester

: 245365-19-9
N-benzyloxy-2-[(4-chloro-benzyl)-(3-trifluoromethyl-benzenesulfonyl)-amino]-3-phenyl-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / polymer-supported phosphazene - BEMP on polystyrene / CH₂Cl₂

2: TFA / CH₂Cl₂

3: CBr₄, NEt₃, polymer-supported triphenylphosphine / CH₂Cl₂

With polystyrene-bound 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; PS-triphenylphosphine; carbon tetrabromide; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0960-894X(99)00311-X

Reference yield:

: 245364-92-5
2-[(4-chloro-benzyl)-(3-trifluoromethyl-benzenesulfonyl)-amino]-3-phenyl-propionic acid tert-butyl ester

: 245365-19-9
N-benzyloxy-2-[(4-chloro-benzyl)-(3-trifluoromethyl-benzenesulfonyl)-amino]-3-phenyl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: TFA / CH₂Cl₂

2: CBr₄, NEt₃, polymer-supported triphenylphosphine / CH₂Cl₂

With PS-triphenylphosphine; carbon tetrabromide; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0960-894X(99)00311-X