N²-tert-butyl-6-fluoro-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide

Base Information

• Chemical Name: N²-tert-butyl-6-fluoro-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide
• CAS No.: 1352086-69-1
• Molecular Formula: C₁₉H₂₃FN₄O₂
• Molecular Weight: 358.416

Synonyms:N²-tert-butyl-6-fluoro-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide

Chemical Property of N²-tert-butyl-6-fluoro-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of N²-tert-butyl-6-fluoro-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide

There total 6 articles about N²-tert-butyl-6-fluoro-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butyl-8-cyano-6-fluoro-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide (1352087-37-6) → N2-tert-butyl-6-fluoro-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide (1352086-69-1)

Guidance literature:

With water; dihydrogen peroxide; sodium hydroxide; In methanol; at 60 ℃; for 18h;

Reference yield:

cinnamic nitrile (1885-38-7) → N2-tert-butyl-6-fluoro-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide (1352086-69-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1.5 h / 20 - 25 °C

2.1: Selectfluor / acetonitrile / 18 h / 60 °C

3.1: sodium hydroxide / tetra(n-butyl)ammonium hydrogensulfate / acetonitrile

3.2: 18 h / 90 °C

4.1: hydrogenchloride / ethanol; water / 2 h / 90 °C

5.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

6.1: sodium hydroxide; water; dihydrogen peroxide / methanol / 18 h / 60 °C

With hydrogenchloride; potassium tert-butylate; water; dihydrogen peroxide; Selectfluor; triethylamine; sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

4-phenyl-1H-pyrrole-3-carbonitrile (40167-37-1) → N2-tert-butyl-6-fluoro-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide (1352086-69-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: Selectfluor / acetonitrile / 18 h / 60 °C

2.1: sodium hydroxide / tetra(n-butyl)ammonium hydrogensulfate / acetonitrile

2.2: 18 h / 90 °C

3.1: hydrogenchloride / ethanol; water / 2 h / 90 °C

4.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

5.1: sodium hydroxide; water; dihydrogen peroxide / methanol / 18 h / 60 °C

With hydrogenchloride; water; dihydrogen peroxide; Selectfluor; triethylamine; sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In methanol; ethanol; dichloromethane; water; acetonitrile;

upstream raw materials:

cinnamic nitrile

4-phenyl-1H-pyrrole-3-carbonitrile

5-fluoro-4-phenyl-1H-pyrrole-3-carbonitrile

tert-butyl {2-[4-cyano-2-fluoro-3-phenyl-1H-pyrrol-1-yl]ethyl}carbamate

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