(5-bromo-2-chloro-phenyl)-(2,3-dihydrobenzofuran-5-yl)methanone

Base Information

• Chemical Name: (5-bromo-2-chloro-phenyl)-(2,3-dihydrobenzofuran-5-yl)methanone
• CAS No.: 1096875-61-4
• Molecular Formula: C₁₅H₁₀BrClO₂
• Molecular Weight: 337.6
• Mol file: 1096875-61-4.mol

Synonyms:(5-bromo-2-chloro-phenyl)-(2,3-dihydrobenzofuran-5-yl)methanone

Chemical Property of (5-bromo-2-chloro-phenyl)-(2,3-dihydrobenzofuran-5-yl)methanone

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5-bromo-2-chloro-phenyl)-(2,3-dihydrobenzofuran-5-yl)methanone

There total 2 articles about (5-bromo-2-chloro-phenyl)-(2,3-dihydrobenzofuran-5-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2.3-dihydrobenzofuran (496-16-2) + 5-bromo-2-chlorobenzoic acid (21739-92-4) → (5-bromo-2-chloro-phenyl)-(2,3-dihydrobenzofuran-5-yl)methanone (1096875-61-4)

Guidance literature:

5-bromo-2-chlorobenzoic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; for 2h;

2.3-dihydrobenzofuran; With aluminum (III) chloride; In dichloromethane; at 5 - 10 ℃; for 3h;

Reference yield:

5-bromo-2-chlorobenzoic acid (21739-92-4) → (5-bromo-2-chloro-phenyl)-(2,3-dihydrobenzofuran-5-yl)methanone (1096875-61-4)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / toluene; N,N-dimethyl-formamide / 5 h / 0 - 100 °C

2: aluminum (III) chloride / dichloromethane / 2 h

With aluminum (III) chloride; thionyl chloride; In dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield: 99.7%

(5-bromo-2-chloro-phenyl)-(2,3-dihydrobenzofuran-5-yl)methanone (1096875-61-4) → (5-bromo-2-chloro-phenyl)-(2,3-dihydrobenzofuran-5-yl)methanol (1282733-55-4)

Guidance literature:

With methanol; sodium tetrahydroborate; In tetrahydrofuran; at 0 ℃; for 0.5h;

upstream raw materials:

5-bromo-2-chlorobenzoic acid

2.3-dihydrobenzofuran

Downstream raw materials:

(5-bromo-2-chloro-phenyl)-(2,3-dihydrobenzofuran-5-yl)methanol

(2S,3R,4S,5S,6R)-2-[4-chloro-3-(2,3-dihydrobenzofuran-5-ylmethyl)phenyl]-6-(hydroxymethyl)-2-methoxy-tetrahydropyran-3,4,5-triol

(2S,3R,4S,5S,6R)-6-[(tert-butyl(dimethyl)silyl)oxymethyl]-2-[4-chloro-3-(2,3-dihydrobenzofuran-5-ylmethyl)phenyl]-2-methoxy-tetrahydropyran-3,4,5-triol

[[(2R,3R,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-(2,3-dihydrobenzofuran-5-ylmethyl)phenyl]-6-methoxy-tetrahydropyran-2-yl]tert-butyl-dimethyl-methoxy]silane