{4-[4-(3,5-bis-trifluoromethyl-benzenesulfonylamino)-phenyl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid methyl ester

Base Information

Chemical Name:{4-[4-(3,5-bis-trifluoromethyl-benzenesulfonylamino)-phenyl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid methyl ester
CAS No.:1451094-60-2
Molecular Formula:C₂₈H₂₀F₇NO₄S
Molecular Weight:599.526
Hs Code.:

Synonyms:{4-[4-(3,5-bis-trifluoromethyl-benzenesulfonylamino)-phenyl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid methyl ester

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Chemical Property of {4-[4-(3,5-bis-trifluoromethyl-benzenesulfonylamino)-phenyl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid methyl ester

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Technology Process of {4-[4-(3,5-bis-trifluoromethyl-benzenesulfonylamino)-phenyl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid methyl ester

There total 10 articles about {4-[4-(3,5-bis-trifluoromethyl-benzenesulfonylamino)-phenyl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1451093-08-5
[4-(4-amino-phenyl)-6-fluoro-3-methyl-naphthalen-2-yl]-acetic acid methyl ester

: 39234-86-1
3,5-bis(trifluoromethyl)benzenesulfonyl chloride

: 1451094-60-2
{4-[4-(3,5-bis-trifluoromethyl-benzenesulfonylamino)-phenyl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid methyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 1451093-09-6
[6-fluoro-3-methyl-4-(4-nitro-phenyl)-naphthalen-2-yl]acetic acid methyl ester

: 1451094-60-2
{4-[4-(3,5-bis-trifluoromethyl-benzenesulfonylamino)-phenyl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: zinc; ammonium chloride / water; tetrahydrofuran; methanol / 0.5 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

With ammonium chloride; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; methanol; water;

Reference yield:

: 1432911-13-1
6-fluoro-4-hydroxy-3-methyl-naphthalene-2-carboxylic acid

: 1451094-60-2
{4-[4-(3,5-bis-trifluoromethyl-benzenesulfonylamino)-phenyl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: sulfuric acid / 0 °C / Reflux

2: potassium carbonate; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

3: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

4: triphenylphosphine; tetrachloromethane / tetrahydrofuran / 2 h / Reflux; Inert atmosphere

5: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 20 °C / Inert atmosphere

6: palladium 10% on activated carbon; hydrogen / methanol

7: pyridine / dichloromethane / 3.17 h / 0 - 20 °C

8: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,2-dimethoxyethane / 0.5 h / 120 °C / Microwave irradiation

9: zinc; ammonium chloride / water; tetrahydrofuran; methanol / 0.5 h / 20 °C

10: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

With pyridine; tetrachloromethane; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium aluminium tetrahydride; sulfuric acid; palladium 10% on activated carbon; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; ammonium chloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; zinc; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;