8-(4-fluorophenyl)-5,6-dihydro-6-methyl-5-oxo-7-pyrido[4,3-b]pyridinecarbonitrile

Base Information

Chemical Name:8-(4-fluorophenyl)-5,6-dihydro-6-methyl-5-oxo-7-pyrido[4,3-b]pyridinecarbonitrile
CAS No.:168542-45-8
Molecular Formula:C₁₆H₁₀FN₃O
Molecular Weight:279.273
Hs Code.:

Synonyms:8-(4-fluorophenyl)-5,6-dihydro-6-methyl-5-oxo-7-pyrido[4,3-b]pyridinecarbonitrile

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Chemical Property of 8-(4-fluorophenyl)-5,6-dihydro-6-methyl-5-oxo-7-pyrido[4,3-b]pyridinecarbonitrile

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Technology Process of 8-(4-fluorophenyl)-5,6-dihydro-6-methyl-5-oxo-7-pyrido[4,3-b]pyridinecarbonitrile

There total 3 articles about 8-(4-fluorophenyl)-5,6-dihydro-6-methyl-5-oxo-7-pyrido[4,3-b]pyridinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 168542-44-7
N-cyanomethyl-N-methyl-2-(4-fluorobenzoyl)-3-pyridinecarboxamide

: 168542-45-8
8-(4-fluorophenyl)-5,6-dihydro-6-methyl-5-oxo-7-pyrido[4,3-b]pyridinecarbonitrile

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; for 7h; Heating;
DOI:10.1248/cpb.45.1642

Reference yield:

: 122853-81-0
2-(4-fluorobenzoyl)-3-pyridinecarboxylic acid

: 168542-45-8
8-(4-fluorophenyl)-5,6-dihydro-6-methyl-5-oxo-7-pyrido[4,3-b]pyridinecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂, DMF / CH₂Cl₂ / 2 h / Heating

2: Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

3: 92 percent / DBU / toluene / 7 h / Heating

With thionyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N,N-dimethyl-formamide; In dichloromethane; toluene;
DOI:10.1248/cpb.45.1642