8-(4-fluorophenyl)-5,6-dihydro-6-methyl-5-oxo-7-pyrido[4,3-b]pyridinecarboxamide

Base Information

Chemical Name:8-(4-fluorophenyl)-5,6-dihydro-6-methyl-5-oxo-7-pyrido[4,3-b]pyridinecarboxamide
CAS No.:168542-46-9
Molecular Formula:C₁₆H₁₂FN₃O₂
Molecular Weight:297.289
Hs Code.:

Synonyms:8-(4-fluorophenyl)-5,6-dihydro-6-methyl-5-oxo-7-pyrido[4,3-b]pyridinecarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-(4-fluorophenyl)-5,6-dihydro-6-methyl-5-oxo-7-pyrido[4,3-b]pyridinecarboxamide

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Technology Process of 8-(4-fluorophenyl)-5,6-dihydro-6-methyl-5-oxo-7-pyrido[4,3-b]pyridinecarboxamide

There total 5 articles about 8-(4-fluorophenyl)-5,6-dihydro-6-methyl-5-oxo-7-pyrido[4,3-b]pyridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 168542-45-8
8-(4-fluorophenyl)-5,6-dihydro-6-methyl-5-oxo-7-pyrido[4,3-b]pyridinecarbonitrile

: 168542-46-9
8-(4-fluorophenyl)-5,6-dihydro-6-methyl-5-oxo-7-pyrido[4,3-b]pyridinecarboxamide

Guidance literature:: With sodium hydroxide; In ethanol; for 1h; Heating;
DOI:10.1248/cpb.45.1642

Reference yield:

: 352-13-6
4-flourophenylmagnesium bromide

: 168542-46-9
8-(4-fluorophenyl)-5,6-dihydro-6-methyl-5-oxo-7-pyrido[4,3-b]pyridinecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 1 h / Ambient temperature

2: SOCl₂, DMF / CH₂Cl₂ / 2 h / Heating

3: Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

4: 92 percent / DBU / toluene / 7 h / Heating

5: 94 percent / 1N aq. NaOH / ethanol / 1 h / Heating

With sodium hydroxide; thionyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; dichloromethane; toluene;
DOI:10.1248/cpb.45.1642

Reference yield:

: 122853-81-0
2-(4-fluorobenzoyl)-3-pyridinecarboxylic acid

: 168542-46-9
8-(4-fluorophenyl)-5,6-dihydro-6-methyl-5-oxo-7-pyrido[4,3-b]pyridinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂, DMF / CH₂Cl₂ / 2 h / Heating

2: Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

3: 92 percent / DBU / toluene / 7 h / Heating

4: 94 percent / 1N aq. NaOH / ethanol / 1 h / Heating

With sodium hydroxide; thionyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N,N-dimethyl-formamide; In ethanol; dichloromethane; toluene;
DOI:10.1248/cpb.45.1642