N⁶-benzoyl-3'-O-[bis(benzyloxy)phosphoryl]-2'-O-(4-methoxybenzyl)adenosine

Base Information

Chemical Name:N⁶-benzoyl-3'-O-[bis(benzyloxy)phosphoryl]-2'-O-(4-methoxybenzyl)adenosine
CAS No.:478050-93-0
Molecular Formula:C₃₉H₃₈N₅O₉P
Molecular Weight:751.733
Hs Code.:

N<sup>6</sup>-benzoyl-3'-O-[bis(benzyloxy)phosphoryl]-2'-O-(4-methoxybenzyl)adenosine

Synonyms:N⁶-benzoyl-3'-O-[bis(benzyloxy)phosphoryl]-2'-O-(4-methoxybenzyl)adenosine

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Chemical Property of N⁶-benzoyl-3'-O-[bis(benzyloxy)phosphoryl]-2'-O-(4-methoxybenzyl)adenosine

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Technology Process of N⁶-benzoyl-3'-O-[bis(benzyloxy)phosphoryl]-2'-O-(4-methoxybenzyl)adenosine

There total 4 articles about N⁶-benzoyl-3'-O-[bis(benzyloxy)phosphoryl]-2'-O-(4-methoxybenzyl)adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 478050-92-9
N⁶-benzoyl-5'-O-dimethoxytrityl-2'-O-(4-methoxybenzyl)-3'-[[bis(benzyloxy)phosphoryl]oxy]adenosine

: 478050-93-0
N⁶-benzoyl-3'-O-[bis(benzyloxy)phosphoryl]-2'-O-(4-methoxybenzyl)adenosine

Guidance literature:: With acetic acid; In water; at 20 ℃; for 2h;
DOI:10.1021/jo0260443

Reference yield:

: 108549-23-1
Dibenzyl N,N-diisopropylphosphoramidite

: 478050-93-0
N⁶-benzoyl-3'-O-[bis(benzyloxy)phosphoryl]-2'-O-(4-methoxybenzyl)adenosine

Guidance literature:: Multi-step reaction with 3 steps

1: tetrazole / CH₂Cl₂ / 1 h

2: 3.5 percent / mCPBA / CH₂Cl₂ / 1 h

3: 74 percent / acetic acid / H₂O / 2 h / 20 °C

With 1H-tetrazole; acetic acid; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water;
DOI:10.1021/jo0260443

Reference yield:

: 80015-60-7
5'-O-dimethoxytrityl-2'-O-(4-methoxybenzyl)-N⁶-benzoyl adenosine

: 478050-93-0
N⁶-benzoyl-3'-O-[bis(benzyloxy)phosphoryl]-2'-O-(4-methoxybenzyl)adenosine

Guidance literature:: Multi-step reaction with 3 steps

1: tetrazole / CH₂Cl₂ / 1 h

2: 3.5 percent / mCPBA / CH₂Cl₂ / 1 h

3: 74 percent / acetic acid / H₂O / 2 h / 20 °C

With 1H-tetrazole; acetic acid; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water;
DOI:10.1021/jo0260443