4-O-Benzyl-3-hydroxy Tyrosol α-Acetate

Base Information

• Chemical Name: 4-O-Benzyl-3-hydroxy Tyrosol α-Acetate
• CAS No.: 1333081-71-2
• Molecular Formula: C₁₇H₁₈O₄
• Molecular Weight: 286.328
• Mol file: 1333081-71-2.mol

Synonyms:C₁₇H₁₈O₄

Chemical Property of 4-O-Benzyl-3-hydroxy Tyrosol α-Acetate

Chemical Property:

• Melting Point: 70-73oC
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

4-O-Benzyl-3-hydroxyTyrosolα-Acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-O-Benzyl-3-hydroxy Tyrosol α-Acetate

There total 5 articles about 4-O-Benzyl-3-hydroxy Tyrosol α-Acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

C18H18O5 (1333081-69-8) → C17H18O4 (1333081-71-2)

Guidance literature:

With methanol; ammonia; at 0 ℃; for 1h;

DOI:10.1016/j.tetlet.2011.07.063

Reference yield:

4-(benzyloxy)-3-formyl phenethyl acetate (1237517-66-6) → C17H18O4 (1333081-71-2)

Guidance literature:

Multi-step reaction with 2 steps

1: diphenyl diselenide; dihydrogen peroxide / dichloromethane / 48 h / 20 °C

2: methanol; ammonia / 1 h / 0 °C

With methanol; diphenyl diselenide; ammonia; dihydrogen peroxide; In dichloromethane; 1: Baeyer-Villiger oxidation;

DOI:10.1016/j.tetlet.2011.07.063

Reference yield:

2-(4-hydroxyphenyl)ethyl acetate (58556-55-1) → C17H18O4 (1333081-71-2)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine; magnesium chloride / 80 °C

2: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 60 °C

3: diphenyl diselenide; dihydrogen peroxide / dichloromethane / 48 h / 20 °C

4: methanol; ammonia / 1 h / 0 °C

With methanol; diphenyl diselenide; ammonia; dihydrogen peroxide; potassium carbonate; triethylamine; sodium iodide; magnesium chloride; In dichloromethane; N,N-dimethyl-formamide; 3: Baeyer-Villiger oxidation;

DOI:10.1016/j.tetlet.2011.07.063

upstream raw materials:

4-(benzyloxy)-3-formyl phenethyl acetate

C₁₈H₁₈O₅

p-hydroxyphenethyl alcohol

2-(4-hydroxyphenyl)ethyl acetate