(1S,2R,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methoxy-1-phenylsulfanyl-butan-2-ol

Base Information

Chemical Name:(1S,2R,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methoxy-1-phenylsulfanyl-butan-2-ol
CAS No.:134678-22-1
Molecular Formula:C₁₇H₃₀O₃SSi
Molecular Weight:342.575
Hs Code.:

Synonyms:(1S,2R,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methoxy-1-phenylsulfanyl-butan-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2R,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methoxy-1-phenylsulfanyl-butan-2-ol

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Technology Process of (1S,2R,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methoxy-1-phenylsulfanyl-butan-2-ol

There total 5 articles about (1S,2R,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methoxy-1-phenylsulfanyl-butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 134592-23-7
(1S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methoxy-1-phenylsulfanyl-butan-2-one

: 134678-22-1
(1S,2R,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methoxy-1-phenylsulfanyl-butan-2-ol

Guidance literature:: With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 ℃;
DOI:10.1016/S0040-4020(01)80909-1

Reference yield:

: 134592-23-7
(1S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methoxy-1-phenylsulfanyl-butan-2-one

: 134678-23-2
(1S,2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methoxy-1-phenylsulfanyl-butan-2-ol

: 134678-22-1
(1S,2R,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methoxy-1-phenylsulfanyl-butan-2-ol

Guidance literature:: With zinc(II) tetrahydroborate; In diethyl ether; dichloromethane; at -78 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1016/S0040-4020(01)80909-1

Reference yield:

: 13865-50-4
methoxymethyl phenyl sulfide

: 134678-22-1
(1S,2R,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methoxy-1-phenylsulfanyl-butan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 1) n-BuLi / 1) THF, hexane, -78 deg C, 1 h

2: Zn(BH₄)2 / CH₂Cl₂; diethyl ether / -78 °C

With n-butyllithium; zinc(II) tetrahydroborate; In diethyl ether; dichloromethane;
DOI:10.1016/S0040-4020(01)80909-1