2-(2-{4-[bis(2-chloroethyl)amino]phenyl}vinyl)-5-methylterephthalonitrile

Base Information

• Chemical Name: 2-(2-{4-[bis(2-chloroethyl)amino]phenyl}vinyl)-5-methylterephthalonitrile
• CAS No.: 1198178-31-2
• Molecular Formula: C₂₁H₁₉Cl₂N₃
• Molecular Weight: 384.308
• Mol file: 1198178-31-2.mol

Synonyms:2-(2-{4-[bis(2-chloroethyl)amino]phenyl}vinyl)-5-methylterephthalonitrile

Chemical Property of 2-(2-{4-[bis(2-chloroethyl)amino]phenyl}vinyl)-5-methylterephthalonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-{4-[bis(2-chloroethyl)amino]phenyl}vinyl)-5-methylterephthalonitrile

There total 6 articles about 2-(2-{4-[bis(2-chloroethyl)amino]phenyl}vinyl)-5-methylterephthalonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-(diethyl phosphorylmethyl)-4-methyl-2,5-dicyanobenzene (952234-25-2) + 4-(bis(2-chloroethyl)amino)benzaldehyde (1208-03-3) → 2-(2-{4-[bis(2-chloroethyl)amino]phenyl}vinyl)-5-methylterephthalonitrile (1198178-31-2)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 ℃; for 12h;

DOI:10.1021/ol200146j

Reference yield:

para-xylene (106-42-3) → 2-(2-{4-[bis(2-chloroethyl)amino]phenyl}vinyl)-5-methylterephthalonitrile (1198178-31-2)

Guidance literature:

Multi-step reaction with 5 steps

1: bromine / dichloromethane / 24 h / 0 - 20 °C

2: N,N-dimethyl-formamide / 24 h / Reflux

3: N-Bromosuccinimide / tetrachloromethane / 3 h / 80 °C

4: 24 h / Reflux

5: sodium hydride / tetrahydrofuran / 12 h / 0 °C

With N-Bromosuccinimide; bromine; sodium hydride; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ol200146j

Reference yield:

2-(bromomethyl)-5-methylterephthalonitrile (952234-24-1) → 2-(2-{4-[bis(2-chloroethyl)amino]phenyl}vinyl)-5-methylterephthalonitrile (1198178-31-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 24 h / Reflux

2: sodium hydride / tetrahydrofuran / 12 h / 0 °C

With sodium hydride; In tetrahydrofuran;

DOI:10.1021/ol200146j

upstream raw materials:

2-(bromomethyl)-5-methylterephthalonitrile

1-(diethyl phosphorylmethyl)-4-methyl-2,5-dicyanobenzene

4-(bis(2-chloroethyl)amino)benzaldehyde

para-xylene

Downstream raw materials:

(E)-2-(4-(4-(pyridin-2-ylmethyl)piperazin-1-yl)styryl)-5-methylterephthalonitrile