952234-25-2

Upstream product

• 952234-24-1 2-(bromomethyl)-5-methylterephthalonitrile 
• 122-52-1 triethyl phosphite 
• 106-42-3 para-xylene 
• 39095-25-5 2,5-dimethylbenzene-1,4-dicarbonitrile 
• 1074-24-4 2,5-dibromo-p-xylene 

Downstream Products

• 1198178-31-2 2-(2-{4-[bis(2-chloroethyl)amino]phenyl}vinyl)-5-methylterephthalonitrile 
• 1273142-85-0 (E)-2-(4-(4-(pyridin-2-ylmethyl)piperazin-1-yl)styryl)-5-methylterephthalonitrile 
• 952234-22-9 (E)-2-methyl-5-(2-(10-octylphenothiazin-3-yl)vinyl)terephthalonitrile 
• 952234-16-1 (E)-2-(3,4,5-trimethoxystyryl)-5-methylterephthalonitrile 
• 952234-15-0 (E)-2-(4-methoxystyryl)-5-methylterephthalonitrile 
• 952234-17-2 (E)-2-(4-cyanostyryl)-5-methylterephthalonitrile 

Relevant academic research and scientific papers

Double-cyano stilbene ethylene two-photon fluorescent solvent chromophore water-soluble probe and its synthetic method and application (by machine translation)

The invention belongs to the technical field of fine chemicals, in particular to double-cyano stilbene ethylene two-photon fluorescent solvent chromophore water-soluble probe and its synthetic method and application, the probe in order to double-cyano stilbene (DCS) for the two-photon fluorescent matrix preparation. The probe molecules of small size, good solubility in water and is suitable for solvent polarity detection, in addition to the fluorescence intensity of the probe, two-photon absorption cross section of the insured with viscosity changes obviously, display a very wide range of solvent chromophore, large two-photon absorption cross section and ultra-large Stokes displacement, thereby greatly improving the detection sensitivity, imaging resolution, sensitivity and transverse and longitudinal resolution, and the accuracy of the test; cell microscopic imaging experiment to demonstrate that its in a cell or tissue has good color range and absorption effect, can be very good detection and reflect cell change in viscosity of the situation, and itself not toxic to the cells. In biological, in the medical field has great application value. (by machine translation)

Double-photon fluorescent probe used for temperature detection and derived from carbazole and preparation method of double-photon fluorescent probe

The invention relates to the technical field of temperature probes, in particular to a double-photon fluorescent probe used for temperature detection and derived from carbazole and a preparation method of the double-photon fluorescent probe. The structural formula of the double-photon fluorescent probe is shown in the description. The fluorescence quantum yield of the probe is high, the detectionrange is wide, the application range of the double-photon fluorescent probe is greatly widened, and the detection reliability is improved.

Preparation method of two-photon fluorescence pH probe and application in cell imaging thereof

The invention belongs to the technical field of fine chemical engineering, and particularly relates to a preparation method of a two-photon fluorescence pH probe and application in cell imaging thereof. The probe is prepared by taking dicyan-biphenyl-ethylene as a matrix, and comprises carbazolyl, di-cyano and n-octyl. Because the molecular structure of the probe has a longer flexible chain, the lipophicity is stronger, the probe can penetrate a cell wall (or cell membrane) into a cell to stain the cell for detecting the pH in the cell; the molecular structure of the probe belongs to D-pi-A type molecules, the two-photon absorption cross section (delta) is improved, so that the probe has higher imaging definition and resolution; in addition, the probe has a large Stokes shift in the marking process, thereby greatly improving the imaging accuracy and precision; the fluorescence quantum yield (phi) of the probe in a solvent is higher, the two-photon emission cross section is larger, so that the higher the brightness of the imaging is, the clearer the image is, and the higher the resolution is.

Two-photon fluorescent sodium ion probe and its synthetic method and application (by machine translation)

The invention belongs to the technical field of fine chemicals, in particular to a two-photon fluorescent sodium ion probe and its synthetic method and application, the probe in order to double-cyano stilbene is two-photon fluorescent matrix preparation. The probe molecules of small volume, to the sodium ion has very good selectivity, but zinc, potassium, calcium, magnesium, manganese, mercury and sodium ion other than the ion detection without interference, can detect micromolar concentration of the sodium ion. After the probe molecule complex sodium fluorescence intensity drop, sodium ion content can be two-photon fluorescence detection. Two-photon fluorescence microscopy imaging experiment shows the type of probe to the fibroblast like cells or tissue permeability, itself is not toxic to the cells, is especially suitable for the cell in the sodium ion concentration change and mercury ion distribution detection, in biological, in the medical field has great application value. (by machine translation)

Dicyanostilbene-derived two-photon fluorescence probe for free zinc ions in live cells and tissues with a large two-photon action cross section

A novel two-photon fluorescence probe for Zn2+ derived from dicyanostilbene as a two-photon fluorophore and 4-(pyridine-2-ylmethyl) piperazine as a novel Zn2+ ligand was developed. The probe shows a 72.5-fold fluorescence enhancement in response to Zn2+, a large two-photon action cross-section (580 GM), a noncytotoxic effect, and pH insensitivity in the biologically relevant range, and its dissociation constant (KdTP) is 0.52 ± 0.01 μM. The probe can selectively detect free Zn2+ ions in live cells for 1500 s or so and in living tissues at a depth of 80-150 μm without interference from other metal ions and the membrane-bound probes.

Dicyanostilbene-derived two-photon fluorescence dyes with large two-photon absorption cross sections

Four dicyanostilbene-derived two-photon fluorescence (TPF) dyes were synthesized as the model compounds to systematically study the effect of the dicyano and the terminal substituent on the two-photon absorption (TPA). These four compounds (DSO, DCY, DTO and DPH) exhibit very large two-photon absorption cross sections (δ). DCY (A-π-A) with the terminal cyano group has especially high fluorescence quantum yield (0.71) and relatively large δ (1480 GM), while DPH (D-π-A) with the substitutedamino group at its terminus possesses the largest δ (2800 GM) and the longest emission wavelength (620 nm). The idealest terminal substituent should not be the alkoxy group but the substitutedamino group. This class of dicyanostilbene dyes possess small molecule size, large δ (830-2800 GM), long-wavelength emission (459-620 nm) and large Stokes shift (80-206 nm), and are ideal chromophores for TPF labels and probes.