(E)-β-[2-hydroxy-4-methoxyphenylethylene]-4-benzyloxy-2-methoxybenzeneethanol

Base Information

• Chemical Name: (E)-β-[2-hydroxy-4-methoxyphenylethylene]-4-benzyloxy-2-methoxybenzeneethanol
• CAS No.: 863310-63-8
• Molecular Formula: C₂₄H₂₄O₅
• Molecular Weight: 392.452
• Mol file: 863310-63-8.mol

Synonyms:(E)-β-[2-hydroxy-4-methoxyphenylethylene]-4-benzyloxy-2-methoxybenzeneethanol

Chemical Property of (E)-β-[2-hydroxy-4-methoxyphenylethylene]-4-benzyloxy-2-methoxybenzeneethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-β-[2-hydroxy-4-methoxyphenylethylene]-4-benzyloxy-2-methoxybenzeneethanol

There total 5 articles about (E)-β-[2-hydroxy-4-methoxyphenylethylene]-4-benzyloxy-2-methoxybenzeneethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 4-benzyloxy-2-methoxyphenylacetate → (E)-β-[2-hydroxy-4-methoxyphenylethylene]-4-benzyloxy-2-methoxybenzeneethanol (863310-63-8)

Guidance literature:

Multi-step reaction with 4 steps

1: NaOH / H₂O

2: KOAc / acetic anhydride / 10 h / 150 °C

3: LAH; AlCl₃ / diethyl ether; tetrahydrofuran / 1.5 h

With sodium hydroxide; potassium acetate; lithium aluminium tetrahydride; aluminium trichloride; In tetrahydrofuran; diethyl ether; water; acetic anhydride;

DOI:10.3987/COM-05-10424

Reference yield:

[4-(benzyloxy)-2-methoxyphenyl]acetic acid (863310-59-2) → (E)-β-[2-hydroxy-4-methoxyphenylethylene]-4-benzyloxy-2-methoxybenzeneethanol (863310-63-8)

Guidance literature:

Multi-step reaction with 3 steps

1: KOAc / acetic anhydride / 10 h / 150 °C

2: LAH; AlCl₃ / diethyl ether; tetrahydrofuran / 1.5 h

With potassium acetate; lithium aluminium tetrahydride; aluminium trichloride; In tetrahydrofuran; diethyl ether; acetic anhydride;

DOI:10.3987/COM-05-10424

Reference yield:

2,4-Dihydroxybenzaldehyde (95-01-2) → (E)-β-[2-hydroxy-4-methoxyphenylethylene]-4-benzyloxy-2-methoxybenzeneethanol (863310-63-8)

Guidance literature:

Multi-step reaction with 3 steps

1: KOAc / acetic anhydride / 10 h / 150 °C

2: LAH; AlCl₃ / diethyl ether; tetrahydrofuran / 1.5 h

With potassium acetate; lithium aluminium tetrahydride; aluminium trichloride; In tetrahydrofuran; diethyl ether; acetic anhydride;

DOI:10.3987/COM-05-10424

upstream raw materials:

3-(4-benzyloxy-2-methoxyphenyl)-7-methoxy-2H-1-benzopyran-2-one

[4-(benzyloxy)-2-methoxyphenyl]acetic acid

3-(4-Benzyloxy-2-methoxy-phenyl)-7-hydroxy-chromen-2-one

2,4-Dihydroxybenzaldehyde

Downstream raw materials:

Vignafuran

2-(4'-Benzyloxy-2-methoxyphenyl)-6-methoxybenzofuran