863310-59-2

Upstream product

• 100-39-0 benzyl bromide 
• 18278-34-7 4-hydroxy-2-methoxybenzaldehyde 
• 58026-14-5 4-(benzyloxy)-2-methoxybenzaldehyde 
• 948571-54-8 tert-butyl [4-(benzyloxy)-2-methoxyphenyl]acetate 
• 171768-67-5 4-benzyloxy-1-bromo-2-methoxybenzene 
• 883985-70-4 2-(4-benzyloxy-2-methoxyphenyl)acetonitrile 

Downstream Products

• 883988-36-1 4-hydroxy-2-methoxyphenylacetic acid 
• 948571-54-8 tert-butyl [4-(benzyloxy)-2-methoxyphenyl]acetate 
• 1437778-87-4 1-(azetidin-1-yl)-2-(4-hydroxy-2-methoxyphenyl)ethanone 
• 1437776-48-1 1-(azetidin-1-yl)-2-[4-(2-{(1S,2R)-2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)-2-methoxyphenyl]ethanone 
• 1437778-86-3 1-(azetidin-1-yl)-2-[4-(benzyloxy)-2-methoxyphenyl]ethanone 
• 948571-52-6 tert-butyl 2-(4-hydroxy-2-methoxyphenyl)acetate 
• 948573-56-6 N-(5-ethyl-1H-pyrazol-3-yl)-2-(4-hydroxy-2-methoxyphenyl)acetamide 
• 948573-59-9 N-(4,5-dimethylisoxazol-3-yl)-2-(4-benzyloxy-2-methoxyphenyl)acetamide 
• 952059-60-8 N-(5-ethylisoxazol-3-yl)-2-(4-hydroxy-2-methoxyphenyl)acetamide 
• 952059-67-5 2-[2-methoxy-4-(1,5-naphthyridin-4-yloxy)phenyl]acetic acid 
• 952059-58-4 tert-butyl 2-[2-methoxy-4-(1,7-naphthyridin-4-yloxy)phenyl]acetate 
• 952059-80-2 2-[2-methoxy-4-(6-methoxy-1,5-naphthyridin-4-yloxy)phenyl]acetic acid 
• 952059-81-3 tert-butyl 2-[2-methoxy-4-(6-methoxy-1,5-naphthyridin-4-yloxy)phenyl]acetate 
• 952059-55-1 2-[2-methoxy-4-(1,7-naphthyridin-4-yloxy)phenyl]acetic acid 

Relevant academic research and scientific papers

SUBSTITUTED CYCLOPROPYL COMPOUNDS USEFUL AS GPR119 AGONISTS

Substituted cyclopropyl compounds of the formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included

NAPHTHYRIDINE DERIVATIVES

The invention concerns naphthyridine derivatives of Formula (Ia) or (Ib) or a pharmaceutically-acceptable salt thereof, wherein each of X1, p, R1, G1, G2, q, R2, R3, R4, R5, Ring A, r and R6 has any of the meanings defined hereinbefore in the description; pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders or disease states associated with angiogenesis and/or vascular permeability.

NAPHTHYRIDINE DERIVATIVES AS ANTI-CANCER AGENTS

The invention concerns naphthyridine derivatives of Formula (I): or a pharmaceutically-acceptable salt thereof, wherein each of X1, p, R1, G1, G2, q, R2, R3, R4, R5, Ring A, r and R6 has any of the meanings defined hereinbefore in the description; pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders or disease states associated with angiogenesis and/or vascular permeability.

QUINOLINE DERIVATIVES

The invention concerns quinoline derivatives of Formula (I): or a pharmaceutically-acceptable salt thereof, wherein each of X1, p, R1, q, R2, R3, R4, R5, Ring A, r and R6 has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders.

QUINAZOLINE DERIVATIVES

The invention concerns quinazoline derivatives of Formula (I) or a pharmaceutically-acceptable salt, solvate or pro-drug thereof, wherein each of X1, p, R1, q, R2, R3, R4, R5, Ring A, r and R6 has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders or in the treatment of disease states associated with angiogenesis and/or vascular permeability.

A short-step convenient synthesis of 2-phenylbenzofuran from 3-phenylcoumarin

The reaction mechanism of chemical conversion of (E)-β-[2-hydroxylphenylethylene]benzeneethanol into 2-phenylbenzofuran by DDQ, which involves loss of one carbon unit, was characterized and described. Five naturally occurring 2-phenylbenzofurans of not only the isoflavonoid but also stilbenoid origin were synthesized by use of this chemical scheme, which proved that this new scheme is a useful tool for quick synthesis of 2-phenylbenzofurans.