N-(3-((4,6-diamino-1,3,5-triazin-2-yl)amino)propyl)-3-(4-(N-(2-iodophenyl)sulfamoyl)phenyl) propanamide4

Base Information

Chemical Name:N-(3-((4,6-diamino-1,3,5-triazin-2-yl)amino)propyl)-3-(4-(N-(2-iodophenyl)sulfamoyl)phenyl) propanamide4
CAS No.:1361574-87-9
Molecular Formula:C₂₁H₂₅IN₈O₃S
Molecular Weight:596.452
Hs Code.:

Synonyms:N-(3-((4,6-diamino-1,3,5-triazin-2-yl)amino)propyl)-3-(4-(N-(2-iodophenyl)sulfamoyl)phenyl) propanamide4

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Chemical Property of N-(3-((4,6-diamino-1,3,5-triazin-2-yl)amino)propyl)-3-(4-(N-(2-iodophenyl)sulfamoyl)phenyl) propanamide4

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Technology Process of N-(3-((4,6-diamino-1,3,5-triazin-2-yl)amino)propyl)-3-(4-(N-(2-iodophenyl)sulfamoyl)phenyl) propanamide4

There total 4 articles about N-(3-((4,6-diamino-1,3,5-triazin-2-yl)amino)propyl)-3-(4-(N-(2-iodophenyl)sulfamoyl)phenyl) propanamide4 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 1158040-51-7
N₂-(3-aminopropyl)-1,3,5-triazine-2,4,6-triamine

: 945654-97-7
3-(4-(N-(2-iodophenyl)sulfamoyl)phenyl)propanoic acid

: 1361574-87-9
N-(3-((4,6-diamino-1,3,5-triazin-2-yl)amino)propyl)-3-(4-(N-(2-iodophenyl)sulfamoyl)phenyl) propanamide4

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 25 ℃; for 18h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.12.018

Reference yield:

: 374537-95-8
methyl 3-[4-(chlorosulfonyl)-phenyl]propanoate

: 1361574-87-9
N-(3-((4,6-diamino-1,3,5-triazin-2-yl)amino)propyl)-3-(4-(N-(2-iodophenyl)sulfamoyl)phenyl) propanamide4

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / tetrahydrofuran / 16 h / 25 °C

2.1: potassium hydroxide / water / 0.5 h / 100 °C

2.2: 1 h / 0 °C / pH 2

3.1: 1-hydroxy-7-aza-benzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 0 - 25 °C / Inert atmosphere

With pyridine; 1-hydroxy-7-aza-benzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.12.018

Reference yield:

: 935684-37-0
methyl 3-{4-[N-(2-iodophenyl)sulfamoyl]phenyl}propanoate

: 1361574-87-9
N-(3-((4,6-diamino-1,3,5-triazin-2-yl)amino)propyl)-3-(4-(N-(2-iodophenyl)sulfamoyl)phenyl) propanamide4

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / water / 0.5 h / 100 °C

1.2: 1 h / 0 °C / pH 2

2.1: 1-hydroxy-7-aza-benzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 0 - 25 °C / Inert atmosphere

With 1-hydroxy-7-aza-benzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.12.018