N-(3-((4,6-diamino-1,3,5-triazin-2-yl)amino)propyl)-3-(4-((2-(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)-1H-indol-1-yl)sulfonyl)phenyl)propanamide

Base Information

Chemical Name:N-(3-((4,6-diamino-1,3,5-triazin-2-yl)amino)propyl)-3-(4-((2-(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)-1H-indol-1-yl)sulfonyl)phenyl)propanamide
CAS No.:1361574-86-8
Molecular Formula:C₂₉H₃₀N₈O₅S
Molecular Weight:602.674
Hs Code.:

Synonyms:N-(3-((4,6-diamino-1,3,5-triazin-2-yl)amino)propyl)-3-(4-((2-(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)-1H-indol-1-yl)sulfonyl)phenyl)propanamide

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Chemical Property of N-(3-((4,6-diamino-1,3,5-triazin-2-yl)amino)propyl)-3-(4-((2-(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)-1H-indol-1-yl)sulfonyl)phenyl)propanamide

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Technology Process of N-(3-((4,6-diamino-1,3,5-triazin-2-yl)amino)propyl)-3-(4-((2-(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)-1H-indol-1-yl)sulfonyl)phenyl)propanamide

There total 9 articles about N-(3-((4,6-diamino-1,3,5-triazin-2-yl)amino)propyl)-3-(4-((2-(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)-1H-indol-1-yl)sulfonyl)phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 935684-39-2
4-ethynyl-4-hydroxycyclohexa-2,5-dien-1-one

: 1361574-87-9
N-(3-((4,6-diamino-1,3,5-triazin-2-yl)amino)propyl)-3-(4-(N-(2-iodophenyl)sulfamoyl)phenyl) propanamide4

: 1361574-86-8
N-(3-((4,6-diamino-1,3,5-triazin-2-yl)amino)propyl)-3-(4-((2-(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)-1H-indol-1-yl)sulfonyl)phenyl)propanamide

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diisopropylamine; In N,N-dimethyl acetamide; water; at 100 ℃; for 0.166667h; Microwave irradiation;
DOI:10.1016/j.bmc.2011.12.018

Reference yield:

: 3-(4-((2-(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)-1H-indol-1-yl)sulfonyl)phenyl)propanoic acid

: 1158040-51-7
N₂-(3-aminopropyl)-1,3,5-triazine-2,4,6-triamine

: 1361574-86-8
N-(3-((4,6-diamino-1,3,5-triazin-2-yl)amino)propyl)-3-(4-((2-(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)-1H-indol-1-yl)sulfonyl)phenyl)propanamide

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 25 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.12.018

Reference yield:

: 374537-95-8
methyl 3-[4-(chlorosulfonyl)-phenyl]propanoate

: 1361574-86-8
N-(3-((4,6-diamino-1,3,5-triazin-2-yl)amino)propyl)-3-(4-((2-(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)-1H-indol-1-yl)sulfonyl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / tetrahydrofuran / 16 h / 25 °C

2.1: potassium hydroxide / water / 0.5 h / 100 °C

2.2: 1 h / 0 °C / pH 2

3.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diisopropylamine / N,N-dimethyl acetamide; water / 0.17 h / 100 °C / Microwave irradiation

4.1: 1-hydroxy-7-aza-benzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 25 °C / Inert atmosphere

With pyridine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1-hydroxy-7-aza-benzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; diisopropylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.12.018