3-(2-bromo-5-hydroxy-4-methoxy-3-methyl-6-phenylmethyl-phenylmethyl)-4-isopropyloxycarbonyl-1-methyl-2,5-piperazinedione

Base Information

• Chemical Name: 3-(2-bromo-5-hydroxy-4-methoxy-3-methyl-6-phenylmethyl-phenylmethyl)-4-isopropyloxycarbonyl-1-methyl-2,5-piperazinedione
• CAS No.: 221146-88-9
• Molecular Formula: C₂₅H₂₉BrN₂O₆
• Molecular Weight: 533.419
• Mol file: 221146-88-9.mol

Synonyms:3-(2-bromo-5-hydroxy-4-methoxy-3-methyl-6-phenylmethyl-phenylmethyl)-4-isopropyloxycarbonyl-1-methyl-2,5-piperazinedione

Chemical Property of 3-(2-bromo-5-hydroxy-4-methoxy-3-methyl-6-phenylmethyl-phenylmethyl)-4-isopropyloxycarbonyl-1-methyl-2,5-piperazinedione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-bromo-5-hydroxy-4-methoxy-3-methyl-6-phenylmethyl-phenylmethyl)-4-isopropyloxycarbonyl-1-methyl-2,5-piperazinedione

There total 12 articles about 3-(2-bromo-5-hydroxy-4-methoxy-3-methyl-6-phenylmethyl-phenylmethyl)-4-isopropyloxycarbonyl-1-methyl-2,5-piperazinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

3-(5-benzyloxy-2-bromo-4-methoxy-3-methylphenylmethyl)-4-isopropyloxycarbonyl-1-methyl-2,5-piperazinedione (221146-84-5) → 3-(2-bromo-5-hydroxy-4-methoxy-3-methylphenylmethyl)-4-isopropyloxycarbonyl-1-methyl-2,5-piperazinedione (221146-87-8) + 3-(2-bromo-5-hydroxy-4-methoxy-3-methyl-6-phenylmethyl-phenylmethyl)-4-isopropyloxycarbonyl-1-methyl-2,5-piperazinedione (221146-88-9)

Guidance literature:

With trifluoroacetic acid; In various solvent(s); at 25 ℃; for 18h;

Reference yield:

2-bromo-5-isopropyloxy-4-methoxy-3-methylbenzaldehyde (287117-38-8) → 3-(2-bromo-5-hydroxy-4-methoxy-3-methyl-6-phenylmethyl-phenylmethyl)-4-isopropyloxycarbonyl-1-methyl-2,5-piperazinedione (221146-88-9)

Guidance literature:

Multi-step reaction with 10 steps

1.1: 74.3 percent / KOtBu / 2-methyl-propan-2-ol; dimethylformamide / 1 h / 20 °C

2.1: NaH / dimethylformamide / 0.5 h / 0 °C

2.2: dimethylformamide / 42 h / 20 °C

3.1: NH₂NH₂*H₂O / dimethylformamide / 1 h / 20 °C

4.1: NaH / dimethylformamide / 0.5 h / 0 °C

4.2: 78.6 percent / dimethylformamide / 3 h / 20 °C

5.1: 85.2 percent / TFA; H₂SO₄ / 1 h / 20 °C

6.1: 88.4 percent / H₂ / 20 percent Pd(OH)2/C / ethanol / 5 h / 760 Torr

7.1: 91 percent / Br₂ / CCl₄; tetrahydrofuran; CH₂Cl₂ / 2 h / 0 °C

8.1: 89.8 percent / K₂CO₃ / dimethylformamide / 3 h / 60 °C

9.1: 94.6 percent / Et₃N; DMAP / CH₂Cl₂ / 4 h / 20 °C

10.1: 30.6 percent / TFA / 18 h / 20 °C

With dmap; sulfuric acid; potassium tert-butylate; hydrogen; bromine; sodium hydride; potassium carbonate; hydrazine hydrate; triethylamine; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1248/cpb.48.1549

Reference yield:

(Z)-3-(2-bromo-5-hydroxy-4-methoxy-3-methylphenylmethylene)-1-methyl-2,5-piperazinedione (310903-96-9) → 3-(2-bromo-5-hydroxy-4-methoxy-3-methyl-6-phenylmethyl-phenylmethyl)-4-isopropyloxycarbonyl-1-methyl-2,5-piperazinedione (221146-88-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 88.4 percent / H₂ / 20 percent Pd(OH)2/C / ethanol / 5 h / 760 Torr

2: 91 percent / Br₂ / CCl₄; tetrahydrofuran; CH₂Cl₂ / 2 h / 0 °C

3: 89.8 percent / K₂CO₃ / dimethylformamide / 3 h / 60 °C

4: 94.6 percent / Et₃N; DMAP / CH₂Cl₂ / 4 h / 20 °C

5: 30.6 percent / TFA / 18 h / 20 °C

With dmap; hydrogen; bromine; potassium carbonate; triethylamine; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.48.1549

upstream raw materials:

3-(5-benzyloxy-2-bromo-4-methoxy-3-methylphenylmethyl)-4-isopropyloxycarbonyl-1-methyl-2,5-piperazinedione

3-(4-methoxy-3-methylphenylmethyl)-1-methyl-2,5-piperazinedione

3-(3-formyl-4-methoxy-5-methylphenylmethyl)-1-methyl-2,5-piperazinedione

3-(3-hydroxy-4-methoxy-5-methylphenylmethyl)-1-methyl-2,5-piperazinedione