3-(2-bromo-5-hydroxy-4-methoxy-3-methylphenylmethyl)-4-isopropyloxycarbonyl-1-methyl-2,5-piperazinedione

Base Information

• Chemical Name: 3-(2-bromo-5-hydroxy-4-methoxy-3-methylphenylmethyl)-4-isopropyloxycarbonyl-1-methyl-2,5-piperazinedione
• CAS No.: 221146-87-8
• Molecular Formula: C₁₈H₂₃BrN₂O₆
• Molecular Weight: 443.294

Synonyms:3-(2-bromo-5-hydroxy-4-methoxy-3-methylphenylmethyl)-4-isopropyloxycarbonyl-1-methyl-2,5-piperazinedione

Chemical Property of 3-(2-bromo-5-hydroxy-4-methoxy-3-methylphenylmethyl)-4-isopropyloxycarbonyl-1-methyl-2,5-piperazinedione

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Technology Process of 3-(2-bromo-5-hydroxy-4-methoxy-3-methylphenylmethyl)-4-isopropyloxycarbonyl-1-methyl-2,5-piperazinedione

There total 16 articles about 3-(2-bromo-5-hydroxy-4-methoxy-3-methylphenylmethyl)-4-isopropyloxycarbonyl-1-methyl-2,5-piperazinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.2%

3-(3-hydroxy-4-methoxy-5-methylphenylmethyl)-4-isopropyloxy-carbonyl-1-methyl-2,5-piperazinedione (221146-80-1) → 3-(2-bromo-5-hydroxy-4-methoxy-3-methylphenylmethyl)-4-isopropyloxycarbonyl-1-methyl-2,5-piperazinedione (221146-87-8)

Guidance literature:

With bromine; In tetrachloromethane; dichloromethane; at 0 ℃; for 1h;

DOI:10.1248/cpb.48.1549

Reference yield: 72.0%

3-(5-benzyloxy-2-bromo-4-methoxy-3-methylphenylmethyl)-4-isopropyloxycarbonyl-1-methyl-2,5-piperazinedione (221146-84-5) → 3-(2-bromo-5-hydroxy-4-methoxy-3-methylphenylmethyl)-4-isopropyloxycarbonyl-1-methyl-2,5-piperazinedione (221146-87-8) + 3-(2-bromo-5-hydroxy-4-methoxy-3-methyl-6-phenylmethyl-phenylmethyl)-4-isopropyloxycarbonyl-1-methyl-2,5-piperazinedione (221146-88-9)

Guidance literature:

With trifluoroacetic acid; In various solvent(s); at 25 ℃; for 18h;

Reference yield: 28.0%

3-(5-benzyloxy-2-bromo-4-methoxy-3-methylphenylmethyl)-4-isopropyloxycarbonyl-1-methyl-2,5-piperazinedione (221146-84-5) → 3-(2-bromo-4,5-dihydroxy-3-methylphenylmethyl)-1-methyl-2,5-piperazinedione + 3-(2-bromo-5-hydroxy-4-methoxy-3-methylphenylmethyl)-4-isopropyloxycarbonyl-1-methyl-2,5-piperazinedione (221146-87-8)

Guidance literature:

With trimethylsilyl iodide; In chloroform; at 50 ℃; for 24h;

upstream raw materials:

3-(5-benzyloxy-2-bromo-4-methoxy-3-methylphenylmethyl)-4-isopropyloxycarbonyl-1-methyl-2,5-piperazinedione

3-(3-hydroxy-4-methoxy-5-methylphenylmethyl)-4-isopropyloxy-carbonyl-1-methyl-2,5-piperazinedione

3-(4-methoxy-3-methylphenylmethyl)-1-methyl-2,5-piperazinedione

3-(3-formyl-4-methoxy-5-methylphenylmethyl)-1-methyl-2,5-piperazinedione

Downstream raw materials:

2-(2-bromo-5-hydroxy-4-methoxy-3-methyl-benzyl)-6-hydroxy-4-methyl-3-oxo-piperazine-1-carboxylic acid isopropyl ester

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