(R)-3-(1-(3-(4-(N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl)sulfamoyl)-2-(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butyl)piperidine-4-carbonyloxy)propylphosphonic acid

Base Information

Chemical Name:(R)-3-(1-(3-(4-(N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl)sulfamoyl)-2-(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butyl)piperidine-4-carbonyloxy)propylphosphonic acid
CAS No.:1619923-36-2
Molecular Formula:C₅₇H₆₆ClF₄N₆O₁₁PS₄
Molecular Weight:1281.87
Hs Code.:

(R)-3-(1-(3-(4-(N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl)sulfamoyl)-2-(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butyl)piperidine-4-carbonyloxy)propylphosphonic acid

Synonyms:(R)-3-(1-(3-(4-(N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl)sulfamoyl)-2-(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butyl)piperidine-4-carbonyloxy)propylphosphonic acid

Suppliers and Price of (R)-3-(1-(3-(4-(N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl)sulfamoyl)-2-(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butyl)piperidine-4-carbonyloxy)propylphosphonic acid

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Chemical Property of (R)-3-(1-(3-(4-(N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl)sulfamoyl)-2-(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butyl)piperidine-4-carbonyloxy)propylphosphonic acid

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of (R)-3-(1-(3-(4-(N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl)sulfamoyl)-2-(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butyl)piperidine-4-carbonyloxy)propylphosphonic acid

There total 58 articles about (R)-3-(1-(3-(4-(N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl)sulfamoyl)-2-(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butyl)piperidine-4-carbonyloxy)propylphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₆₃H₈₂ClF₄N₆O₁₁PS₄Si₂

: 1619923-36-2
(R)-3-(1-(3-(4-(N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl)sulfamoyl)-2-(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butyl)piperidine-4-carbonyloxy)propylphosphonic acid

Guidance literature:: With water; In acetonitrile; Reagent/catalyst; Inert atmosphere;

Reference yield:

: 1244724-97-7
(R)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(phenylthio)butanoic acid

: 1619923-36-2
(R)-3-(1-(3-(4-(N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl)sulfamoyl)-2-(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butyl)piperidine-4-carbonyloxy)propylphosphonic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / 1,2-dimethoxyethane / -8 °C / Inert atmosphere

1.2: 0.75 h / -15 °C / Inert atmosphere

2.1: diethylamine / acetonitrile / 12 h / Large scale

2.2: 12 h / 25 °C / Large scale

3.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 20 °C / Large scale

4.1: dichloromethane / 1 h / 20 °C

4.2: 20 °C

5.1: sodium hydroxide; water / tetrahydrofuran / 20 °C / Large scale

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 4 h / 20 °C / Inert atmosphere; Large scale

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; t-butyldimethylsiyl triflate / dichloromethane / 2 h / 5 - 15 °C / Inert atmosphere; Large scale

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

9.1: acetonitrile / 1 h / 60 °C / Inert atmosphere

10.1: water / acetonitrile / Inert atmosphere

With 4-methyl-morpholine; dmap; t-butyldimethylsiyl triflate; water; sulfur trioxide pyridine complex; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; isobutyl chloroformate; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 188813-02-7
3-bromo-5-fluorobenzaldehyde

: 1619923-36-2
(R)-3-(1-(3-(4-(N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl)sulfamoyl)-2-(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butyl)piperidine-4-carbonyloxy)propylphosphonic acid

Guidance literature:: Multi-step reaction with 12 steps

1.1: triphenylphosphine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran / -85 - -70 °C / Inert atmosphere

2.2: -85 - -70 °C / Inert atmosphere

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 25 °C / Inert atmosphere

4.1: acetic anhydride / 100 - 110 °C / Inert atmosphere

5.1: palladium diacetate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; sodium t-butanolate / toluene / 50 - 110 °C / Inert atmosphere

6.1: ethanol; acetyl chloride / dichloromethane / 0 - 20 °C / Inert atmosphere

7.1: potassium carbonate / dimethyl sulfoxide / 55 - 65 °C / Inert atmosphere

8.1: hydrogen / tetrahydrofuran / 20 °C

9.1: pyridine / tetrahydrofuran; dichloromethane / -5 °C

10.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

11.1: acetonitrile / 1 h / 60 °C / Inert atmosphere

12.1: water / acetonitrile / Inert atmosphere

With pyridine; ethanol; water; hydrogen; palladium diacetate; acetic anhydride; potassium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; acetyl chloride; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; sodium t-butanolate; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene; acetonitrile;