N-(2-(4-(4-fluorobenzyl)-1H-imidazol-2-yl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-5-methyl-1,2-oxazole-3-carboxamide

Base Information

Chemical Name:N-(2-(4-(4-fluorobenzyl)-1H-imidazol-2-yl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-5-methyl-1,2-oxazole-3-carboxamide
CAS No.:1380647-04-0
Molecular Formula:C₂₆H₂₅FN₆O₄
Molecular Weight:504.521
Hs Code.:

N-(2-(4-(4-fluorobenzyl)-1H-imidazol-2-yl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-5-methyl-1,2-oxazole-3-carboxamide

Synonyms:N-(2-(4-(4-fluorobenzyl)-1H-imidazol-2-yl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-5-methyl-1,2-oxazole-3-carboxamide

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Chemical Property of N-(2-(4-(4-fluorobenzyl)-1H-imidazol-2-yl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-5-methyl-1,2-oxazole-3-carboxamide

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Technology Process of N-(2-(4-(4-fluorobenzyl)-1H-imidazol-2-yl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-5-methyl-1,2-oxazole-3-carboxamide

There total 7 articles about N-(2-(4-(4-fluorobenzyl)-1H-imidazol-2-yl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-5-methyl-1,2-oxazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 39499-34-8
5-methyl-3-isoxazolyl chloride

: 1380647-01-7
10-amino-2-[4-[(4-fluorophenyl)methyl]-1H-imidazol-2-yl]-7,8,9,10-tetrahydro-3-hydroxy-7,10-ethanopyrimido[1,2-a]azepin-4(6H)-one

: 1380647-04-0
N-(2-(4-(4-fluorobenzyl)-1H-imidazol-2-yl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-5-methyl-1,2-oxazole-3-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 1188429-06-2
ethyl 10-(((benzyloxy)carbonyl)amino)-3-hydroxy-4-oxo-4,6,7,8,9,10-hexahydro-7,10-ethanopyrimido[1,2-a] azepine-2-carboxylate

: 1380647-04-0
N-(2-(4-(4-fluorobenzyl)-1H-imidazol-2-yl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-5-methyl-1,2-oxazole-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 50 °C

2: water; lithium hydroxide monohydrate / ethanol / 16 h / 20 °C

3: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h

4: triethylamine / dichloromethane / 16 h / 20 °C

5: triphenylphosphine; tetrachloromethane / acetonitrile / 16 h / 45 °C

6: formic acid / palladium 10% on activated carbon / methanol / 3 h / 40 °C

7: triethylamine / dichloromethane / 16 h / 20 °C

With tetrachloromethane; formic acid; oxalyl dichloride; lithium hydroxide monohydrate; water; potassium carbonate; triethylamine; triphenylphosphine; palladium 10% on activated carbon; N,N-dimethyl-formamide; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: C₂₇H₂₆ClN₃O₅

: 1380647-04-0
N-(2-(4-(4-fluorobenzyl)-1H-imidazol-2-yl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-5-methyl-1,2-oxazole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 16 h / 20 °C

2: triphenylphosphine; tetrachloromethane / acetonitrile / 16 h / 45 °C

3: formic acid / palladium 10% on activated carbon / methanol / 3 h / 40 °C

4: triethylamine / dichloromethane / 16 h / 20 °C

With tetrachloromethane; formic acid; triethylamine; triphenylphosphine; palladium 10% on activated carbon; In methanol; dichloromethane; acetonitrile;