10-amino-2-[4-[(4-fluorophenyl)methyl]-1H-imidazol-2-yl]-7,8,9,10-tetrahydro-3-hydroxy-7,10-ethanopyrimido[1,2-a]azepin-4(6H)-one

Base Information

Chemical Name:10-amino-2-[4-[(4-fluorophenyl)methyl]-1H-imidazol-2-yl]-7,8,9,10-tetrahydro-3-hydroxy-7,10-ethanopyrimido[1,2-a]azepin-4(6H)-one
CAS No.:1380647-01-7
Molecular Formula:C₂₁H₂₂FN₅O₂
Molecular Weight:395.436
Hs Code.:

Synonyms:10-amino-2-[4-[(4-fluorophenyl)methyl]-1H-imidazol-2-yl]-7,8,9,10-tetrahydro-3-hydroxy-7,10-ethanopyrimido[1,2-a]azepin-4(6H)-one

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Chemical Property of 10-amino-2-[4-[(4-fluorophenyl)methyl]-1H-imidazol-2-yl]-7,8,9,10-tetrahydro-3-hydroxy-7,10-ethanopyrimido[1,2-a]azepin-4(6H)-one

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Technology Process of 10-amino-2-[4-[(4-fluorophenyl)methyl]-1H-imidazol-2-yl]-7,8,9,10-tetrahydro-3-hydroxy-7,10-ethanopyrimido[1,2-a]azepin-4(6H)-one

There total 6 articles about 10-amino-2-[4-[(4-fluorophenyl)methyl]-1H-imidazol-2-yl]-7,8,9,10-tetrahydro-3-hydroxy-7,10-ethanopyrimido[1,2-a]azepin-4(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1380647-30-2
benzyl (3-(benzyloxy)-2-(4-chloro-5-(4-fluorobenzyl)-1H-imidazol-2-yl)-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)carbamate

: 1380647-01-7
10-amino-2-[4-[(4-fluorophenyl)methyl]-1H-imidazol-2-yl]-7,8,9,10-tetrahydro-3-hydroxy-7,10-ethanopyrimido[1,2-a]azepin-4(6H)-one

Guidance literature:: benzyl (3-(benzyloxy)-2-(4-chloro-5-(4-fluorobenzyl)-1H-imidazol-2-yl)-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)carbamate; With formic acid; palladium 10% on activated carbon; In methanol; at 40 ℃; for 3h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 1188429-06-2
ethyl 10-(((benzyloxy)carbonyl)amino)-3-hydroxy-4-oxo-4,6,7,8,9,10-hexahydro-7,10-ethanopyrimido[1,2-a] azepine-2-carboxylate

: 1380647-01-7
10-amino-2-[4-[(4-fluorophenyl)methyl]-1H-imidazol-2-yl]-7,8,9,10-tetrahydro-3-hydroxy-7,10-ethanopyrimido[1,2-a]azepin-4(6H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 50 °C

2: water; lithium hydroxide monohydrate / ethanol / 16 h / 20 °C

3: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h

4: triethylamine / dichloromethane / 16 h / 20 °C

5: triphenylphosphine; tetrachloromethane / acetonitrile / 16 h / 45 °C

6: formic acid / palladium 10% on activated carbon / methanol / 3 h / 40 °C

With tetrachloromethane; formic acid; oxalyl dichloride; lithium hydroxide monohydrate; water; potassium carbonate; triethylamine; triphenylphosphine; palladium 10% on activated carbon; N,N-dimethyl-formamide; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1380647-29-9
benzyl (3-(benzyloxy)-2-((1-cyano-2-(4-fluorophenyl)ethyl)carbamoyl)-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)carbamate

: 1380647-01-7
10-amino-2-[4-[(4-fluorophenyl)methyl]-1H-imidazol-2-yl]-7,8,9,10-tetrahydro-3-hydroxy-7,10-ethanopyrimido[1,2-a]azepin-4(6H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; tetrachloromethane / acetonitrile / 16 h / 45 °C

2: formic acid / palladium 10% on activated carbon / methanol / 3 h / 40 °C

With tetrachloromethane; formic acid; triphenylphosphine; palladium 10% on activated carbon; In methanol; acetonitrile;