ethyl (2S)-ethoxy-3-[4-(5-methyl-2-thiophen-2-yloxazol-4-ylethoxy)phenyl]propanoate

Base Information

Chemical Name:ethyl (2S)-ethoxy-3-[4-(5-methyl-2-thiophen-2-yloxazol-4-ylethoxy)phenyl]propanoate
CAS No.:696661-53-7
Molecular Formula:C₂₃H₂₇NO₅S
Molecular Weight:429.537
Hs Code.:

Synonyms:ethyl (2S)-ethoxy-3-[4-(5-methyl-2-thiophen-2-yloxazol-4-ylethoxy)phenyl]propanoate

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Chemical Property of ethyl (2S)-ethoxy-3-[4-(5-methyl-2-thiophen-2-yloxazol-4-ylethoxy)phenyl]propanoate

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Technology Process of ethyl (2S)-ethoxy-3-[4-(5-methyl-2-thiophen-2-yloxazol-4-ylethoxy)phenyl]propanoate

There total 7 articles about ethyl (2S)-ethoxy-3-[4-(5-methyl-2-thiophen-2-yloxazol-4-ylethoxy)phenyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(5-methyl-2-thien-2-yl-1,3-oxazol-4-yl)ethyl methanesulfonate

: 222555-06-8
ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate

: 696661-53-7
ethyl (2S)-ethoxy-3-[4-(5-methyl-2-thiophen-2-yloxazol-4-ylethoxy)phenyl]propanoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 - 90 ℃; for 2h;
DOI:10.1016/j.bmcl.2011.03.020

Reference yield:

: 98-03-3
thiophene-2-carbaldehyde

: 696661-53-7
ethyl (2S)-ethoxy-3-[4-(5-methyl-2-thiophen-2-yloxazol-4-ylethoxy)phenyl]propanoate

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogenchloride; acetic acid / 1 h / 0 °C

2: trichlorophosphate / 1,2-dichloro-ethane / 14 h / Reflux

3: N,N-dimethyl-formamide / 4 h / 25 - 30 °C

4: sulfuric acid; water / 16 h / Reflux

5: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 10 °C

6: triethylamine / dichloromethane / 2 h / 25 °C

7: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 - 90 °C

With hydrogenchloride; lithium aluminium tetrahydride; sulfuric acid; water; potassium carbonate; acetic acid; triethylamine; trichlorophosphate; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.03.020

Reference yield:

: 403611-87-0
C₁₀H₈N₂OS

: 696661-53-7
ethyl (2S)-ethoxy-3-[4-(5-methyl-2-thiophen-2-yloxazol-4-ylethoxy)phenyl]propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid; water / 16 h / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 10 °C

3: triethylamine / dichloromethane / 2 h / 25 °C

4: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 - 90 °C

With lithium aluminium tetrahydride; sulfuric acid; water; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.03.020