Technology Process of trans-2-phenyl-2-(N-piperidinyl)bicyclo<3.1.0>hexane
There total 4 articles about trans-2-phenyl-2-(N-piperidinyl)bicyclo<3.1.0>hexane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 60 ℃;
for 72h;
DOI:10.1021/jm00403a014
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 98 percent / chromic acid / diethyl ether / 3 h / Ambient temperature
2: 42 percent / diethyl ether; cyclohexane / 1.) -70 deg C, 10 min, 2.) 20 deg C, 20 min
3: 1.) sodium azide, trifluoroacetic acid, 2. ) LAH / 1.) CHCl3, room temperature, 4 h, 2.) ether, reflux, 3 h
4: 77 percent / K2CO3 / dimethylformamide / 72 h / 60 °C
With
lithium aluminium tetrahydride; sodium azide; chromic acid; potassium carbonate; trifluoroacetic acid;
In
diethyl ether; cyclohexane; N,N-dimethyl-formamide;
DOI:10.1021/jm00403a014
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 42 percent / diethyl ether; cyclohexane / 1.) -70 deg C, 10 min, 2.) 20 deg C, 20 min
2: 1.) sodium azide, trifluoroacetic acid, 2. ) LAH / 1.) CHCl3, room temperature, 4 h, 2.) ether, reflux, 3 h
3: 77 percent / K2CO3 / dimethylformamide / 72 h / 60 °C
With
lithium aluminium tetrahydride; sodium azide; potassium carbonate; trifluoroacetic acid;
In
diethyl ether; cyclohexane; N,N-dimethyl-formamide;
DOI:10.1021/jm00403a014