[(2S,3R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid pentafluorophenyl ester

Base Information

Chemical Name:[(2S,3R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid pentafluorophenyl ester
CAS No.:195519-91-6
Molecular Formula:C₃₉H₃₃F₅N₂O₈
Molecular Weight:752.692
Hs Code.:

[(2S,3R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid pentafluorophenyl ester

Synonyms:[(2S,3R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid pentafluorophenyl ester

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Chemical Property of [(2S,3R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid pentafluorophenyl ester

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Technology Process of [(2S,3R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid pentafluorophenyl ester

There total 4 articles about [(2S,3R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid pentafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 14533-84-7
pentafluorophenyl trifloroacetate

: 195519-90-5
[(2S,3R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid

: 195519-91-6
[(2S,3R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid pentafluorophenyl ester

Guidance literature:: With pyridine; In N,N-dimethyl-formamide; for 16h; Ambient temperature;
DOI:10.1002/hlca.19970800517

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 195519-91-6
[(2S,3R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / 4-(dimethylamino)pyridine / pyridine / 16 h / 0 °C

2: 62 percent / pyridine / dimethylformamide / 16 h / Ambient temperature

With pyridine; triethylamine; dmap; In pyridine; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19970800517

Reference yield:

: 172033-24-8
[(2S,3R,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid

: 195519-91-6
[(2S,3R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Bu₄NF / tetrahydrofuran / 5 h / Ambient temperature

2: Et₃N / 4-(dimethylamino)pyridine / pyridine / 16 h / 0 °C

3: 62 percent / pyridine / dimethylformamide / 16 h / Ambient temperature

With pyridine; tetrabutyl ammonium fluoride; triethylamine; dmap; In tetrahydrofuran; pyridine; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19970800517