methyl 2-(3-((3-benzyl-4-oxo-3,4-dihydrophthalazin-1-yl)-methyl)-5-chloro-2-methyl-1H-indol-1-yl)acetate

Base Information

Chemical Name:methyl 2-(3-((3-benzyl-4-oxo-3,4-dihydrophthalazin-1-yl)-methyl)-5-chloro-2-methyl-1H-indol-1-yl)acetate
CAS No.:1297284-50-4
Molecular Formula:C₂₈H₂₄ClN₃O₃
Molecular Weight:485.97
Hs Code.:

Synonyms:methyl 2-(3-((3-benzyl-4-oxo-3,4-dihydrophthalazin-1-yl)-methyl)-5-chloro-2-methyl-1H-indol-1-yl)acetate

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Chemical Property of methyl 2-(3-((3-benzyl-4-oxo-3,4-dihydrophthalazin-1-yl)-methyl)-5-chloro-2-methyl-1H-indol-1-yl)acetate

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Technology Process of methyl 2-(3-((3-benzyl-4-oxo-3,4-dihydrophthalazin-1-yl)-methyl)-5-chloro-2-methyl-1H-indol-1-yl)acetate

There total 6 articles about methyl 2-(3-((3-benzyl-4-oxo-3,4-dihydrophthalazin-1-yl)-methyl)-5-chloro-2-methyl-1H-indol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1297284-49-1
2-benzyl-4-((5-chloro-2-methyl-1H-indol-3-yl)methyl)-phthalazin-1(2H)-one

: 96-32-2
bromoacetic acid methyl ester

: 1297284-50-4
methyl 2-(3-((3-benzyl-4-oxo-3,4-dihydrophthalazin-1-yl)-methyl)-5-chloro-2-methyl-1H-indol-1-yl)acetate

Guidance literature:: 2-benzyl-4-((5-chloro-2-methyl-1H-indol-3-yl)methyl)-phthalazin-1(2H)-one; bromoacetic acid methyl ester; With potassium carbonate; In N,N-dimethyl-formamide; at 85 ℃; for 0.266667h; Inert atmosphere;

at 20 ℃;

Reference yield:

: 1075-35-0
5-chloro-2-methylindole

: 1297284-50-4
methyl 2-(3-((3-benzyl-4-oxo-3,4-dihydrophthalazin-1-yl)-methyl)-5-chloro-2-methyl-1H-indol-1-yl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 20 °C

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

3.1: sodium acetate / toluene / 16 h / 200 °C / Inert atmosphere

4.1: hydrazine / isopropyl alcohol / 16 h / Inert atmosphere; Reflux

5.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 85 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 0.27 h / 85 °C / Inert atmosphere

6.2: 20 °C

With n-butyllithium; water; sodium acetate; potassium carbonate; lithium hydroxide; hydrazine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

Reference yield:

: 172595-66-3
methyl 2-(5-chloro-2-methyl-1H-indol-3-yl)acetate

: 1297284-50-4
methyl 2-(3-((3-benzyl-4-oxo-3,4-dihydrophthalazin-1-yl)-methyl)-5-chloro-2-methyl-1H-indol-1-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

2.1: sodium acetate / toluene / 16 h / 200 °C / Inert atmosphere

3.1: hydrazine / isopropyl alcohol / 16 h / Inert atmosphere; Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 85 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 0.27 h / 85 °C / Inert atmosphere

5.2: 20 °C

With water; sodium acetate; potassium carbonate; lithium hydroxide; hydrazine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; isopropyl alcohol; toluene;