2-benzyl-4-((5-chloro-2-methyl-1H-indol-3-yl)methyl)-phthalazin-1(2H)-one

Base Information

Chemical Name:2-benzyl-4-((5-chloro-2-methyl-1H-indol-3-yl)methyl)-phthalazin-1(2H)-one
CAS No.:1297284-49-1
Molecular Formula:C₂₅H₂₀ClN₃O
Molecular Weight:413.906
Hs Code.:

Synonyms:2-benzyl-4-((5-chloro-2-methyl-1H-indol-3-yl)methyl)-phthalazin-1(2H)-one

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Chemical Property of 2-benzyl-4-((5-chloro-2-methyl-1H-indol-3-yl)methyl)-phthalazin-1(2H)-one

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Technology Process of 2-benzyl-4-((5-chloro-2-methyl-1H-indol-3-yl)methyl)-phthalazin-1(2H)-one

There total 5 articles about 2-benzyl-4-((5-chloro-2-methyl-1H-indol-3-yl)methyl)-phthalazin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1297284-48-0
4-((5-chloro-2-methyl-1H-indol-3-yl)methyl)phthalazin-1(2H)-one

: 100-39-0
benzyl bromide

: 1297284-49-1
2-benzyl-4-((5-chloro-2-methyl-1H-indol-3-yl)methyl)-phthalazin-1(2H)-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 85 ℃; for 16h;

Reference yield:

: 1075-35-0
5-chloro-2-methylindole

: 1297284-49-1
2-benzyl-4-((5-chloro-2-methyl-1H-indol-3-yl)methyl)-phthalazin-1(2H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 20 °C

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

3.1: sodium acetate / toluene / 16 h / 200 °C / Inert atmosphere

4.1: hydrazine / isopropyl alcohol / 16 h / Inert atmosphere; Reflux

5.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 85 °C

With n-butyllithium; water; sodium acetate; potassium carbonate; lithium hydroxide; hydrazine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

Reference yield:

: 172595-66-3
methyl 2-(5-chloro-2-methyl-1H-indol-3-yl)acetate

: 1297284-49-1
2-benzyl-4-((5-chloro-2-methyl-1H-indol-3-yl)methyl)-phthalazin-1(2H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

2: sodium acetate / toluene / 16 h / 200 °C / Inert atmosphere

3: hydrazine / isopropyl alcohol / 16 h / Inert atmosphere; Reflux

4: potassium carbonate / N,N-dimethyl-formamide / 16 h / 85 °C

With water; sodium acetate; potassium carbonate; lithium hydroxide; hydrazine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; isopropyl alcohol; toluene;