N-methyl-N-phenylanthranilic acid methyl ester

Base Information

• Chemical Name: N-methyl-N-phenylanthranilic acid methyl ester
• CAS No.: 169170-03-0
• Molecular Formula: C₁₅H₁₅NO₂
• Molecular Weight: 241.29
• Mol file: 169170-03-0.mol

Synonyms:N-methyl-N-phenylanthranilic acid methyl ester

Chemical Property of N-methyl-N-phenylanthranilic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-methyl-N-phenylanthranilic acid methyl ester

There total 18 articles about N-methyl-N-phenylanthranilic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-(N-Methyl-N-phenylamino)-benzoic acid (73323-82-7) + methyl iodide (74-88-4) → N-methyl-N-phenylanthranilic acid methyl ester (169170-03-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 12h; Ambient temperature;

DOI:10.1039/a800868j

Reference yield: 87.0%

carbon dioxide (124-38-9,18923-20-1) + N,N-dimethyl-aniline (121-69-7,77733-26-7) + 2-(trimethylsilyl)phenyl trifluoromethanesulfonate (88284-48-4) → N-methyl-N-phenylanthranilic acid methyl ester (169170-03-0)

Guidance literature:

carbon dioxide; N,N-dimethyl-aniline; With potassium fluoride; 18-crown-6 ether; In tetrahydrofuran; at -10 ℃; for 0.0833333h; Sealed tube; Glovebox;

2-(trimethylsilyl)phenyl trifluoromethanesulfonate; In tetrahydrofuran; at -30 - 60 ℃; for 24h; Sealed tube; Glovebox;

DOI:10.1021/acs.orglett.6b02845

Reference yield: 80.0%

Methyl N-phenylanthranilate (35708-19-1) + dimethyl sulfate (77-78-1) → N-methyl-N-phenylanthranilic acid methyl ester (169170-03-0)

Guidance literature:

With 15-crown-5; sodium hydride; In tetrahydrofuran; 1,2-dimethoxyethane; mineral oil; at 0 - 20 ℃; for 120h; Inert atmosphere;

DOI:10.1021/jo200280c

upstream raw materials:

2-(phenylamino)benzoic acid

methyl iodide

2-(N-Methyl-N-phenylamino)-benzoic acid

N-methylaniline

Downstream raw materials:

N-Methyl 9,9-bis-(4-hydroxyphenyl)-(9H)-acridine

N-methoxy-2-(methyl(phenyl)amino)benzamide

2-(methyl(phenyl)amino)-N-phenylbenzamide

5-methyl-10-phenyl-5H-dibenzo[b,e][1,4]diazepin-11(10H)-one