4-amino-N-[3-tert-butyl-2-methoxy-5-(2-methoxy-3-pyridyl)phenyl]benzamide

Base Information

Chemical Name:4-amino-N-[3-tert-butyl-2-methoxy-5-(2-methoxy-3-pyridyl)phenyl]benzamide
CAS No.:1206776-57-9
Molecular Formula:C₂₄H₂₇N₃O₃
Molecular Weight:405.497
Hs Code.:

Synonyms:4-amino-N-[3-tert-butyl-2-methoxy-5-(2-methoxy-3-pyridyl)phenyl]benzamide

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Chemical Property of 4-amino-N-[3-tert-butyl-2-methoxy-5-(2-methoxy-3-pyridyl)phenyl]benzamide

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Technology Process of 4-amino-N-[3-tert-butyl-2-methoxy-5-(2-methoxy-3-pyridyl)phenyl]benzamide

There total 5 articles about 4-amino-N-[3-tert-butyl-2-methoxy-5-(2-methoxy-3-pyridyl)phenyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1206774-41-5
N-[3-tert-butyl-2-methoxy-5-(2-methoxy-3-pyridyl)phenyl]-4-nitrobenzamide

: 1206776-57-9
4-amino-N-[3-tert-butyl-2-methoxy-5-(2-methoxy-3-pyridyl)phenyl]benzamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; ethyl acetate; for 0.333333h; Inert atmosphere;
DOI:10.1021/jm401266k

Reference yield:

: 474554-50-2
5-bromo-1-tert-butyl-2-methoxy-3-nitrobenzene

: 1206776-57-9
4-amino-N-[3-tert-butyl-2-methoxy-5-(2-methoxy-3-pyridyl)phenyl]benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane; methanol / 0.58 h / 115 °C / Microwave irradiation; Inert atmosphere

2: hydrogen; palladium 10% on activated carbon / methanol; ethyl acetate / 16 h / 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere

4: hydrogen; palladium 10% on activated carbon / methanol; ethyl acetate / 0.33 h / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium carbonate; triethylamine; In methanol; dichloromethane; ethyl acetate; 1: |Suzuki Coupling;
DOI:10.1021/jm401266k

Reference yield:

: 1206774-40-4
3-tert-butyl-2-methoxy-5-(2-methoxy-3-pyridyl)aniline

: 1206776-57-9
4-amino-N-[3-tert-butyl-2-methoxy-5-(2-methoxy-3-pyridyl)phenyl]benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere

2: hydrogen; palladium 10% on activated carbon / methanol; ethyl acetate / 0.33 h / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm401266k