N-[3-tert-butyl-2-methoxy-5-(2-methoxy-3-pyridyl)phenyl]-4-nitrobenzamide

Base Information

Chemical Name:N-[3-tert-butyl-2-methoxy-5-(2-methoxy-3-pyridyl)phenyl]-4-nitrobenzamide
CAS No.:1206774-41-5
Molecular Formula:C₂₄H₂₅N₃O₅
Molecular Weight:435.48
Hs Code.:

Synonyms:N-[3-tert-butyl-2-methoxy-5-(2-methoxy-3-pyridyl)phenyl]-4-nitrobenzamide

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Chemical Property of N-[3-tert-butyl-2-methoxy-5-(2-methoxy-3-pyridyl)phenyl]-4-nitrobenzamide

Chemical Property:

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Technology Process of N-[3-tert-butyl-2-methoxy-5-(2-methoxy-3-pyridyl)phenyl]-4-nitrobenzamide

There total 4 articles about N-[3-tert-butyl-2-methoxy-5-(2-methoxy-3-pyridyl)phenyl]-4-nitrobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1206774-40-4
3-tert-butyl-2-methoxy-5-(2-methoxy-3-pyridyl)aniline

: 122-04-3
4-nitro-benzoyl chloride

: 1206774-41-5
N-[3-tert-butyl-2-methoxy-5-(2-methoxy-3-pyridyl)phenyl]-4-nitrobenzamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jm401266k

Reference yield:

: 1206774-39-1
3-(3-tert-butyl-4-methoxy-5-nitrophenyl)-2-methoxypyridine

: 1206774-41-5
N-[3-tert-butyl-2-methoxy-5-(2-methoxy-3-pyridyl)phenyl]-4-nitrobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / methanol; ethyl acetate / 16 h / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm401266k

Reference yield:

: 474554-50-2
5-bromo-1-tert-butyl-2-methoxy-3-nitrobenzene

: 1206774-41-5
N-[3-tert-butyl-2-methoxy-5-(2-methoxy-3-pyridyl)phenyl]-4-nitrobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane; methanol / 0.58 h / 115 °C / Microwave irradiation; Inert atmosphere

2: hydrogen; palladium 10% on activated carbon / methanol; ethyl acetate / 16 h / 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium carbonate; triethylamine; In methanol; dichloromethane; ethyl acetate; 1: |Suzuki Coupling;
DOI:10.1021/jm401266k